| Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine. | |
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MedLine Citation:
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PMID: 2153047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human cell line HL-60 was used to investigate the role of protein kinase C in the regulation of retinoic acid-induced maturation of promyelocytic leukemia cells by growth and differentiation factors found in serum. Cells grown in serum-containing medium differentiated less than cells in serum-free medium due to several factors, including albumin binding of retinoic acid. Addition of an inhibitor (sphinganine) of protein kinase C, an enzyme that participates in cellular responses to many serum factors, facilitated the retinoic acid-induced differentiation. Cells treated with both retinoic acid and sphinganine produced more superoxide when stimulated by formylmethionylleucylphenylalanine; hence, this combination generated a more functional population of cells. The ability of sphinganine to promote retinoic acid-induced differentiation suggests that retinoic acid therapy might be improved by the concurrent use of a modulator of protein kinase C activity. |
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Authors:
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V L Stevens; N E Owens; E F Winton; J M Kinkade; A H Merrill |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 50 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-02-13 Completed Date: 1990-02-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 222-6 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Emory University, Atlanta, Georgia 30322. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Physiological Phenomena* Cell Differentiation / drug effects Humans Leukemia, Promyelocytic, Acute / metabolism, pathology* N-Formylmethionine Leucyl-Phenylalanine / pharmacology Protein Kinase C / physiology Sphingosine / analogs & derivatives*, pharmacology Superoxides / metabolism Tetradecanoylphorbol Acetate / pharmacology Tretinoin / metabolism, pharmacology*, therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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CA22294/CA/NCI NIH HHS; CA46508/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11062-77-4/Superoxides; 123-78-4/Sphingosine; 16561-29-8/Tetradecanoylphorbol Acetate; 302-79-4/Tretinoin; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine; 764-22-7/safingol; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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