| Modulation of retinal blood flow by kinin B(1) receptor in Streptozotocin-diabetic rats. | |
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MedLine Citation:
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PMID: 21420952 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The vasoactive kinin B(1) receptor (B(1)R) is overexpressed in the retina of diabetic rats in response to hyperglycaemia and oxidative stress. The aim of the present study was to determine whether B(1)R could contribute to the early retinal blood flow changes occurring in diabetes. Male Wistar rats were rendered diabetic with a single i.p. injection of Streptozotocin (STZ) and studied 4 days or 6 weeks after diabetes induction. The presence of B(1)R in the retina was confirmed by Western blot. The impact of oral administration of the B(1)R selective antagonist SSR240612 (10mg/kg) was measured on alteration of retinal perfusion in awaked diabetic rats by quantitative autoradiography. Data showed that B(1)R was upregulated in the STZ-diabetic retina at 4 days and 6 weeks. Retinal blood flow was not altered in 4-day diabetic rats compared with age-matched controls but was significantly decreased following SSR240612 treatment. In 6-week diabetic rats, retinal blood flow was markedly reduced compared to control rats and SSR240612 did not further decrease the blood flow. These results suggest that B(1)R is upregulated in STZ-diabetic retina and has a protective compensatory role on retinal microcirculation at 4 days but not at 6 weeks following diabetes induction. |
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Authors:
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Mylène Pouliot; Simon Hétu; Karim Lahjouji; Réjean Couture; Elvire Vaucher |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-18 |
Journal Detail:
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Title: Experimental eye research Volume: - ISSN: 1096-0007 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370707 Medline TA: Exp Eye Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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École d'optométrie, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, QC, Canada, H3C 3J7; Département de Physiologie, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, QC, Canada, H3C 3J7. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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