Document Detail

Modulation of the response to estradiol-17beta of rat vascular tissues by a non calcemic vitamin D analog.
MedLine Citation:
PMID:  15225797     Owner:  NLM     Status:  MEDLINE    
Estradiol-17beta (E(2)) increases creatine kinase (CK) specific activity in aorta (Ao) and left ventricle of the heart (Lv) from rat females. In the present study, we analyzed the effects of pretreatment with the non calcemic analog of vitamin D, JK 1624 F2-2 (JKF) on the response to E(2) (either 0.5 or 5 microg/rat) of Ao and Lv from prepubertal female rats. JKF did not affect CK in either organ. However, pretreatment with JKF (0.1 ng/g body weight for 1 or 2 weeks) increased the CK response to E(2) (0.5 microg/rat) by 50 +/- 10% in Ao and by 150 +/- 12% in Lv. The CK response to 5 microg/rat of E(2) in intact female rats, was increased by 118 +/- 15% and 99 +/- 11% in the Ao and by 89 +/- 6% and 112 +/- 13% in the Lv, in animals treated daily with JKF for 1 or 2 weeks, respectively, before administration of E(2). JKF also increased the response to 500 microg/rat raloxifene (Ral) by 47 +/- 8% in Ao and by 56 +/- 12% in Lv. Preliminary experiments showed that JKF treatment induced a approximately 50% increase in estradiol receptor ERalpha in both organs. The results indicate that the vitamin D analog JKF upregulates the response and sensitivity of vascular tissues to E(2), in association with increased expression of their ERalpha. These results should prompt examination of the possibility that the effects estrogen therapy in postmenopausal women can be augmented by vitamin D or its analogs.
Dalia Somjen; Sara Katzburg; Merav Baz; Naftali Stern; Gary H Posner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of steroid biochemistry and molecular biology     Volume:  89-90     ISSN:  0960-0760     ISO Abbreviation:  J. Steroid Biochem. Mol. Biol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-06-30     Completed Date:  2004-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015483     Medline TA:  J Steroid Biochem Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  339-41     Citation Subset:  IM    
Tel-Aviv Sourasky Medical Center, Institute of Endocrinology, Metabolism and Hypertension, 6 Weizman St., Tel-Aviv 64239, Israel.
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MeSH Terms
Aorta / drug effects*
Calcitriol / analogs & derivatives*,  pharmacology*
Estradiol / pharmacology*
Heart Ventricles / drug effects*
Rats, Wistar
Reg. No./Substance:
0/JK 1624F2-1; 32222-06-3/Calcitriol; 50-28-2/Estradiol

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