Document Detail

Modulation of the response of a rodent fibrosarcoma to photodynamic therapy by hyperbaric-oxygen treatment.
MedLine Citation:
PMID:  21597746     Owner:  NLM     Status:  In-Data-Review    
The ability of hyperbaric oxygen (HBO) treatment to modulate the response of a rodent fibrosarcoma to interstitial photodynamic therapy (PDT) using 630 nm light and intravenous polyhaematoporphyrin (PHP) was examined. Application of HBO for 30 min immediately prior to PDT resulted in a light dose-dependent increase in tumour growth retardation, maximum effect (+227%) being observed with 100J light, and no enhancement being seen at or above 400J. Application of HBO during or immediately after PDT had no effect on response. Reducing the interval between giving PHP and administering light from the usual 48 h to just 1 h increased the efficacy of PDT even in the absence of HBO pre-treatment. Under these circumstances, application of HBO did not realise any further increase in tumour response at any light dose. Our findings suggest that manipulation of tumour oxygenation may be able to improve the outcome of PDT under some circumstances, but that careful consideration of other treatment variables, such as light dose and drug-to-light interval, may provide similar, more easily achievable, improvements in efficacy.
D Roberts; F Cairnduff; B Dixon; S Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  2     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  1995 May 
Date Detail:
Created Date:  2011-05-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  387-90     Citation Subset:  -    
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