| Modulation of the renin-aldosterone system by iodotyrosines as tyrosine hydroxylase inhibitors. | |
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MedLine Citation:
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PMID: 1981135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study shows that MIT and DIT stimulate aldosterone secretion. This may be due to their tyrosine hydroxylase inhibitory property. Dopamine abolishes the stimulation. Prolonged MIT administration enhances the stimulation of aldosterone secretion and can cause hypokalemia. Volume expansion reverses the hyperaldosteronism. PRA and blood pressure do not change, even after prolonged MIT intake. |
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Authors:
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S A Tan; L S Berk; L G Tan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical medicine and metabolic biology Volume: 44 ISSN: 0885-4505 ISO Abbreviation: Biochem. Med. Metab. Biol. Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-04-01 Completed Date: 1991-04-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8605718 Medline TA: Biochem Med Metab Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 252-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Loma Linda University, California 92350. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / secretion* Diiodotyrosine / pharmacology Dopamine / pharmacology Humans Hyperaldosteronism / chemically induced Hypokalemia / chemically induced Male Monoiodotyrosine / pharmacology* Renin-Angiotensin System / drug effects*, physiology Tyrosine 3-Monooxygenase / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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29592-76-5/Monoiodotyrosine; 52-39-1/Aldosterone; 66-02-4/Diiodotyrosine; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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