| Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate. | |
| | |
MedLine Citation:
|
PMID: 21092375 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The effect of raw cabbage and sauerkraut juices on the expression and activity of phase II enzymes, glutathione S-transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1), in the rat liver and kidney was compared with that of two commercially available products of glucosinolate degradation: indole-3-carbinol (I3C) and phenethyl isothiocyanate (PEITC). Male Wistar rats were treated by oral administration with cabbage juices, I3C or PEITC for 4, 10 and 30 d. The results showed that juices, particularly sauerkraut juice as with I3C and PEITC, significantly increased GST and NQO1 activities in the rat liver. The only exception was the 30 d time point of feeding with raw cabbage juice. Cabbage juices, I3C and PEITC affected the hepatic GST μ to the greatest extent and GST α to a lesser extent. The results of the present study also showed that the treatment of rats with juices and compounds tested caused the translocation of the NF-E2-related transcription factor (Nrf2) active subunit from the cytosol to the nucleus, providing an argument for the involvement of this transcription factor in the induction of GST and NQO1. In contrast to the liver, cabbage juices affected only the renal GST θ, while treatment with I3C and PEITC significantly increased the activity of NQO1. Thus, the results of the present study indicate that induction of the key detoxifying enzymes by cabbage juices, particularly sauerkraut, may be responsible for their chemopreventive activity demonstrated by epidemiological studies and in animal models. However, the final effects might be organ or tissue dependent. |
| | |
Authors:
|
Violetta Krajka-Kuźniak; Hanna Szaefer; Agnieszka Bartoszek; Wanda Baer-Dubowska |
Related Documents
:
|
3124755 - Prostaglandin d2 formation and characterization of its synthetases in various tissues o... 7741235 - Effect of selenium depletion on thyroidal type-i iodothyronine deiodinase activity in i... 8874805 - Cellular antioxidant defense by a ubiquinol-regenerating system coupled with cytosolic ... 9433915 - Spaceflight downregulates antioxidant defense systems in rat liver. 393365 - Effects of suprachiasmatic nucleus lesions on hypothalamic lh-releasing hormone (lhrh) ... 11145935 - Endothelial dysfunction and denudation in rat aortic allografts. |
Publication Detail:
|
Type: Journal Article Date: 2010-11-23 |
Journal Detail:
|
Title: The British journal of nutrition Volume: 105 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-03-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 816-26 Citation Subset: IM |
Affiliation:
|
Department of Pharmaceutical Biochemistry, University of Medical Sciences, Święcickiego 4, 60-781 Poznań, Poland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition of gametogenesis by the cestode Ligula intestinalis in roach ( Rutilus rutilus) is attenu...
Next Document: Regulatory mechanisms of intestinal folate uptake in a rat model of folate oversupplementation.