| Modulation of radiation-induced oral mucositis (mouse) by selective inhibition of β1 integrin. | |
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MedLine Citation:
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PMID: 22841020 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Oral mucositis is a severe side effect of radio(chemo)therapy for head and neck tumors, for which β1 integrins have been proposed as potential therapeutic targets. The present study was initiated to determine the effect of selective inhibition of β1 integrin on the oral epithelial radiation response. MATERIALS AND METHODS: Daily fractionated irradiation was given with 5×3Gy/week over 1 or 2weeks with/without the β1 integrin-inhibiting monoclonal antibody AIIB2 or an IgG control. Each protocol was terminated by graded test doses to generate full dose-effect curves for mucosal ulceration. The same technique was used for single dose irradiation. RESULTS: Combined single dose irradiation plus AIIB2 resulted in a significant decrease of the ED50 compared to irradiation alone or control IgG. No effect of AIIB2 was found with fractionated irradiation over 1week. With 2weeks of fractionation, AIIB2 induced a significant increase in the ED50 for the terminating test irradiation when administered in week 2. The time course of the response was largely unaffected by β1 integrin inhibition. CONCLUSIONS: A reduction of mucosal reactions by β1 integrin inhibition later in a course of fractionation was observed, i.e. when epithelial repopulation processes were active. Further mechanistic studies are required. |
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Authors:
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Maria Albert; Margret Schmidt; Nils Cordes; Wolfgang Dörr |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-25 |
Journal Detail:
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Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Volume: - ISSN: 1879-0887 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8407192 Medline TA: Radiother Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Dept. of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Germany, Medical Faculty Carl Gustav Carus, Technical University Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Germany, Medical Faculty Carl Gustav Carus, Technical University Dresden, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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