Document Detail


Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanine.
MedLine Citation:
PMID:  1833509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quinolinic acid, an endogenous excitotoxin, and kynurenic acid, an antagonist of excitatory amino acid receptors, are believed to be synthesized from tryptophan after the opening of the indole ring. They were measured in the rat brain and other organs using gas chromatography-mass spectrometry or HPLC. The enzyme indoleamine 2,3-dioxygenase, capable of cleaving the indole ring of tryptophan, was induced by administering bacterial endotoxins to rats, which significantly increased the brain content of both quinolinic and kynurenic acids. Nicotinylalanine, an analogue of kynurenine, inhibited this endotoxin-induced accumulation of quinolinic acid while potentiating the accumulation of kynurenic acid. The possibility of significantly increasing brain concentrations of kynurenic acid without a concomitant increase in quinolinic acid may provide a useful approach for studying the role of these electrophysiologically active tryptophan metabolites in brain function and preventing the possible toxic actions of abnormal synthesis of quinolinic acid.
Authors:
F Moroni; P Russi; M A Gallo-Mezo; G Moneti; R Pellicciari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  57     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-11-15     Completed Date:  1991-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1630-5     Citation Subset:  IM    
Affiliation:
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
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MeSH Terms
Descriptor/Qualifier:
Alanine / analogs & derivatives*,  pharmacology
Animals
Brain / drug effects,  metabolism*
Endotoxins / pharmacology*
Escherichia coli
Gas Chromatography-Mass Spectrometry
Kidney / metabolism
Kynurenic Acid / blood,  metabolism*
Lipopolysaccharides / toxicity*
Liver / metabolism
Male
Models, Neurological
Niacin / analogs & derivatives*,  pharmacology
Organ Specificity
Quinolinic Acid
Quinolinic Acids / metabolism*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Endotoxins; 0/Lipopolysaccharides; 0/Quinolinic Acids; 137548-54-0/nicotinylalanine; 492-27-3/Kynurenic Acid; 56-41-7/Alanine; 59-67-6/Niacin; 89-00-9/Quinolinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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