Document Detail

Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids.
MedLine Citation:
PMID:  20041999     Owner:  NLM     Status:  MEDLINE    
Chronic inflammation is known to promote the development of many chronic diseases. Pattern recognition receptors (PRRs), Toll-like receptors (TLRs), and nucleotide-binding oligomerization domain proteins (NODs) mediate both infection-induced inflammation and sterile inflammation by recognizing pathogen- associated molecular patterns and endogenous molecules, respectively. PRR-mediated inflammation is an important determinant in altering the risk of many chronic diseases. Saturated fatty acids (SFAs) can activate PRRs, leading to enhanced expression of pro-inflammatory target gene products. However, n-3 polyunsaturated fatty acids (PUFAs) inhibit agonist-induced activation of PRRs. These results suggest that SFAs and n-3 PUFAs can reciprocally modulate PRR-mediated inflammation, and that PRRs and their downstream signaling components are molecular targets for dietary strategies to reduce chronic inflammation and subsequent risk of chronic diseases. This advancement in knowledge provides a new paradigm for understanding the mechanism by which different dietary fatty acids modify risk of chronic diseases including insulin resistance, atherosclerosis, and cancer.
Joo Y Lee; Ling Zhao; Daniel H Hwang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  68     ISSN:  1753-4887     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-31     Completed Date:  2010-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-61     Citation Subset:  IM    
Western Human Nutrition Research Center, ARS, USDA and Department of Nutrition, University of California, Davis, CA, USA.
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MeSH Terms
Chronic Disease / prevention & control
Dietary Fats*
Fatty Acids* / metabolism,  physiology
Fatty Acids, Omega-3 / metabolism,  physiology
Inflammation / physiopathology*
Nod Signaling Adaptor Proteins / agonists,  antagonists & inhibitors,  physiology
Receptors, Pattern Recognition / agonists,  antagonists & inhibitors,  physiology*
Risk Factors
Toll-Like Receptors / agonists,  antagonists & inhibitors,  physiology
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Nod Signaling Adaptor Proteins; 0/Receptors, Pattern Recognition; 0/Toll-Like Receptors

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