Document Detail

Modulation of oxygen-free radicals from human leukocytes during halothane- and enflurane- induced general anesthesia.
MedLine Citation:
PMID:  3434166     Owner:  NLM     Status:  MEDLINE    
Oxidative metabolism correlates with the release of microbiocidal oxygen-free radicals, measured as luminol-dependent chemiluminescence. The effect of general anesthesia on the oxidative metabolism of human leukocytes was investigated. Sixteen patients undergoing a halothane-induced general anesthesia and 14 patients receiving an enflurane-induced general anesthesia participated in the study. Halothane-induced anesthesia was accompanied both by a suppression of basic chemiluminescence and by a decrease in chemiluminescence during the phagocytosis of zymosan A. This was monitored 15 min, 30 min and 60 min after starting general anesthesia and compared to the level of chemiluminescence before starting general anesthesia. Ninety minutes after finishing general anesthesia, a significant recovery of chemiluminescence was seen to exceed the level before general anesthesia. Comparable findings were observed with enflurane-induced general anesthesia, suggesting a decreased release of oxygen-free radicals during general anesthesia, and afterwards an increase exceeding the initial level.
J Barth; W Petermann; P Entzian; C Wustrow; J Wustrow; E E Ohnhaus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  31     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-03-10     Completed Date:  1988-03-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  740-3     Citation Subset:  IM    
Department of Internal Medicine, University of Kiel, FRG.
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MeSH Terms
Aged, 80 and over
Anesthesia, General*
Anesthesia, Intratracheal
Enflurane / pharmacology*
Free Radicals
Halothane / pharmacology*
Immunity, Innate / drug effects
Luminescent Measurements
Middle Aged
Monocytes / drug effects*
Neutrophils / drug effects*
Otorhinolaryngologic Diseases / surgery
Oxygen / blood*
Reg. No./Substance:
0/Free Radicals; 13838-16-9/Enflurane; 151-67-7/Halothane; 7782-44-7/Oxygen

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