Document Detail

Modulation of normal and altered hippocampal excitability states by septal networks.
MedLine Citation:
PMID:  17393499     Owner:  NLM     Status:  MEDLINE    
The septal region of the basal forebrain plays a dual role: 1) It modulates hippocampal excitability, facilitating synaptic plasticity within hippocampal circuits. Through this mechanism, the septum facilitates diverse cognitive processes that involve hippocampal circuits. 2) Additionally, the septum maintains the hippocampal networks working within normal ranges, decreasing the probability of abnormal excitability states. Through this second mechanism, the septum prevents the occurrence of epileptic discharges. Thus, septal alterations may lead to both decreased cognitive functions and epilepsy, as observed in elderly patients affected with Alzheimer's disease.
Luis V Colom; Emilio Garrido-Sanabria
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  85     ISSN:  0360-4012     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2008-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2839-43     Citation Subset:  IM    
Copyright Information:
2007 Wiley-Liss, Inc.
Department of Biological Sciences, Center for Biomedical Studies, The University of Texas at Brownsville, Brownsville, Texas 78520, USA.
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MeSH Terms
Hippocampus / physiology*
Nerve Net / physiology*
Neuronal Plasticity / physiology*
Septum of Brain / anatomy & histology*

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