| Modulation of the natriuretic peptide system in heart failure: from bench to bedside? | |
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MedLine Citation:
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PMID: 12710884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since the discovery of atrial natriuretic peptide, the unravelling of the natriuretic peptide system has been a story of scientific success. However, bridging the gap between bench and bedside has proved difficult, and as yet has not provided any major clinical progress. In this review we will first give a detailed outline of the key elements constituting the natriuretic peptide system. Secondly, we will briefly explain the underlying rationale, basic concepts and evidence behind currently pursued strategies to potentiate the natriuretic peptide system. Thirdly, we will highlight some of the problems that have so far hindered successful translation of these theoretically viable treatment options into tangible clinical progress. |
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Authors:
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Matthias Schmitt; John R Cockcroft; Michael P Frenneaux |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 105 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-22 Completed Date: 2003-09-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 141-60 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Academic Avenue, Cardiff CF14 4XN, UK. matthschmitt@doctors.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / physiology Cardiotonic Agents / therapeutic use Heart Failure / drug therapy, physiopathology* Humans Mice Natriuretic Peptide, Brain / physiology Natriuretic Peptide, C-Type / physiology Peptide Hormones / physiology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Peptide Hormones; 114471-18-0/Natriuretic Peptide, Brain; 127869-51-6/Natriuretic Peptide, C-Type; 85637-73-6/Atrial Natriuretic Factor |
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