Document Detail

Modulation of mutagenic activity in meat samples after deep-frying in vegetable oils.
MedLine Citation:
PMID:  11752235     Owner:  NLM     Status:  MEDLINE    
Previous studies have been carried out on the influence of frying fats on the formation of food mutagens, but most of them have been performed on model systems or under cooking conditions that are more frequent in northern countries. The objective of this work was to study the overall mutagenic activity generated in hamburgers and frankfurters deep-fried under cooking conditions that are normal practice in Spain and other Mediterranean countries, in order to determine if there was any modulation of the mutagenic activity with respect to other cooking conditions previously studied. Hamburgers were prepared from beef purchased in a butcher's shop. Frankfurters as well as the oils [olive, marc olive ('orujo'), sunflower and soya bean oil] and butter were purchased in a local supermarket. The samples were fried in a teflon-coated frying pan at 170-180 degrees C for 10, 20 or 30 min. The mutagens were extracted and the mutagenic activity evaluated using the Salmonella mammalian microsome assay with strain TA98. Two independent assays were carried out for each experimental condition. All the hamburgers showed a mutagenic activity that was more than four times higher than that of the controls. Frankfurters showed a lower mutagenic activity than hamburgers (fried under the same conditions) because they have a lower protein content and a higher fat content. Hamburgers fried in olive oil for 10 min showed a significant increase in the number of revertants with respect to the other oils, probably due to the fact that the temperature reached was approximately 10 degrees C higher. Longer frying times significantly increased the number of revertants in samples fried in oils, except in olive oil, probably due to its lower content of polyunsaturated fatty acids.
C Perez; A Lopez de Cerain; J Bello
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Mutagenesis     Volume:  17     ISSN:  0267-8357     ISO Abbreviation:  Mutagenesis     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-25     Completed Date:  2002-05-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8707812     Medline TA:  Mutagenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Department of Food Science and Toxicology, Faculty of Pharmacy, University of Navarra, E-31080 Pamplona, Spain.
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MeSH Terms
Cookery / methods*
Hot Temperature*
Meat / analysis*
Microsomes, Liver / metabolism
Mutagenicity Tests
Plant Oils*
Salmonella typhimurium / drug effects,  genetics
Soybean Oil
Reg. No./Substance:
0/Plant Oils; 8001-21-6/sunflower seed oil; 8001-22-7/Soybean Oil; 8001-25-0/olive oil; 8029-34-3/Butter

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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