Document Detail


Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.
MedLine Citation:
PMID:  23055184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rate of mutations in eukaryotes depends on a plethora of factors and is not immediately derived from the fidelity of DNA polymerases (Pols). Replication of chromosomes containing the anti-parallel strands of duplex DNA occurs through the copying of leading and lagging strand templates by a trio of Pols α, δ and ϵ, with the assistance of Pol ζ and Y-family Pols at difficult DNA template structures or sites of DNA damage. The parameters of the synthesis at a given location are dictated by the quality and quantity of nucleotides in the pools, replication fork architecture, transcription status, regulation of Pol switches, and structure of chromatin. The result of these transactions is a subject of survey and editing by DNA repair.
Authors:
Irina S-R Waisertreiger; Victoria G Liston; Miriam R Menezes; Hyun-Min Kim; Kirill S Lobachev; Elena I Stepchenkova; Tahir H Tahirov; Igor B Rogozin; Youri I Pavlov
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2012-10-10
Journal Detail:
Title:  Environmental and molecular mutagenesis     Volume:  53     ISSN:  1098-2280     ISO Abbreviation:  Environ. Mol. Mutagen.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-01-08     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  8800109     Medline TA:  Environ Mol Mutagen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  699-724     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA Replication*
DNA-Directed DNA Polymerase / metabolism
Humans
Mutagenesis*
Nucleotides / metabolism*
Grant Support
ID/Acronym/Agency:
2011-27//PHS HHS; 5P20RR016469/RR/NCRR NIH HHS; 8P20GM103427/GM/NIGMS NIH HHS; CA129925/CA/NCI NIH HHS; P20 GM103427/GM/NIGMS NIH HHS; P20 RR016469/RR/NCRR NIH HHS; R01 CA129925/CA/NCI NIH HHS; R01 GM082923/GM/NIGMS NIH HHS; R01GM0825950/GM/NIGMS NIH HHS; R01GM082923/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Nucleotides; EC 2.7.7.7/DNA-Directed DNA Polymerase
Comments/Corrections

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