Document Detail

Modulation of mustard toxicity by tacrine.
MedLine Citation:
PMID:  8117327     Owner:  NLM     Status:  MEDLINE    
Compounds containing the chloroethyl group are potent inhibitors of DNA synthesis and cell growth. Tacrine, a choline carrier inhibitor, was found to protect both HeLa cells and rat thymocytes against the effects of nitrogen mustard. DNA synthesis was restored from 13 to 71% of the control value and cell viability restored from 27 to 57% of the control value by exposure of the cells to an equimolar concentration of tacrine immediately prior to nitrogen mustard. In contrast, tacrine was unable to significantly protect rat thymocytes against the toxic effects of sulphur mustard. These results have implications for the clinical use of nitrogen mustard.
P Gray; K Lewis; A Masta; D Phillips
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  47     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-03-25     Completed Date:  1994-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  581-3     Citation Subset:  IM    
Materials Research Laboratory, Defence Science and Technology Organisation, Ascot Vale, Australia.
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MeSH Terms
Cell Survival
Cells, Cultured / drug effects
DNA / biosynthesis
Hela Cells / drug effects
Mechlorethamine / antagonists & inhibitors,  toxicity*
Mustard Gas / toxicity
Rats, Sprague-Dawley
Tacrine / pharmacology*
Reg. No./Substance:
321-64-2/Tacrine; 505-60-2/Mustard Gas; 51-75-2/Mechlorethamine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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