Document Detail

Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate.
MedLine Citation:
PMID:  2313378     Owner:  NLM     Status:  MEDLINE    
This study examines whether oleate may influence the linoleate enhanced metastasis of line 4526 murine mammary tumors. In addition, the in vitro proliferative response of line 4526 to oleate and other selected fatty acids was assessed. Initially, the tumor cells were grown in a defined medium supplemented with palmitate, stearate, oleate, linoleate, linolenate or arachidonate. The unsaturated fatty acids stimulated and the saturated fatty acids inhibited proliferation compared to fatty acid-free medium. Next, we examined the effect of oleate on the linoleate enhanced metastasis of 4526 tumors by substituting oleate for saturated fat in isoenergetic diets containing high or low levels of linoleate. Oleate had no effect on metastasis in mice fed the high linoleate diets but it significantly increased metastasis in mice fed the low linoleate diets. Finally, the fatty acid compositions of tumors and mammary fat pads were compared to diet fatty acid compositions and metastatic frequency. Metastasis corresponded more closely to total unsaturated fatty acids than to total polyunsaturated fatty acids or to any individual fatty acid. These studies suggest that both mono- and polyunsaturated fatty acids may stimulate mammary tumor metastasis. However, the influence of dietary oleate probably depends on the level of linoleate and total unsaturated fatty acids in the diet.
D K Buckman; R S Chapkin; K L Erickson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  120     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-20     Completed Date:  1990-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  148-57     Citation Subset:  IM    
Department of Human Anatomy, University of California, School of Medicine, Davis 95616.
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MeSH Terms
Body Weight
Cell Division / drug effects
Dietary Fats, Unsaturated / analysis,  pharmacology*
Dose-Response Relationship, Drug
Fatty Acids / analysis,  toxicity
Linoleic Acid
Linoleic Acids / toxicity*
Mammary Neoplasms, Experimental / analysis,  diet therapy,  pathology*
Mice, Inbred BALB C
Neoplasm Metastasis*
Oleic Acid
Oleic Acids / therapeutic use*
Organ Size
Tumor Cells, Cultured
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Linoleic Acids; 0/Oleic Acids; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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