Document Detail

Modulation of morphological changes of endometrial surface epithelium by administration of composite root extract in albino rat.
MedLine Citation:
PMID:  11024229     Owner:  NLM     Status:  MEDLINE    
In the present investigation, we attempted to study the modulation of morphological changes of endometrial surface epithelium by Scanning Electron Microscope (SCEM) in the adult albino rat after oral administration of roots extract. The origin of this experiment lies in the fact that the dry powdered roots of five plants, i.e., Plumbago rosea, Borassus flabellifer, Carica papaya (male), Dolichos lablab, and Shorea robusta in mixed form, has been traditionally used by the folk women of this region through oral route during the first seven days of a menstrual cycle to prevent conception. Ethanolic crude extract of these roots in composite form which has been referred to here as composite root extract (CRE) was administered to the adult female albino rat in a dose of 1000 mg/kg body weight/day through oral route continuously for 12 days starting from proestrous. The observations under SCEM showed that administration of the CRE induced morphological changes of the endometrial surface epithelium in albino rat uterus. The characteristic smooth regular pattern of normal epithelium appears to have been changed at places by haphazardly oriented groups of cells and loss of microvilli indicating a disorganized picture. This structural disparity has been thought to affect the smooth functioning of nidatory preparation in the endometrium.
H N Sarma; H C Mahanta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contraception     Volume:  62     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-10-25     Completed Date:  2000-11-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-4     Citation Subset:  IM    
Department of Zoology, Arunachal University, 791 111, Itanagar, India.
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MeSH Terms
Administration, Oral
Endometrium / cytology,  drug effects*
Epithelial Cells / cytology,  drug effects*,  ultrastructure
Microscopy, Electron, Scanning
Microvilli / drug effects,  ultrastructure
Plant Extracts / administration & dosage,  pharmacology*
Plant Roots*
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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