Document Detail

Modulation of membrane fluidity in a fatty acid auxotrophe of Tetrahymena thermophila.
MedLine Citation:
PMID:  7349876     Owner:  NLM     Status:  MEDLINE    
A mutant of Tetrahymena thermophila has been isolated which requires an unsaturated fatty acid for growth. Pellicles isolated from cultures supplemented with palmitoleic, elaidic, oleic, linoleic and gamma-linolenic acids show widely differing membrane fluidities, as measured by the polarisation of fluorescence technique. In contrast to the behaviour of the wild type organism, the changes in fluidity of the membrane, once induced by supplementation, are permanent. This mutant should prove extremely useful for studying structure-function relationships in the various membrane systems of Tetrahymena.
R J Hill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  595     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1980  
Date Detail:
Created Date:  1980-02-28     Completed Date:  1980-02-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM    
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MeSH Terms
Cell Membrane / physiology
Fatty Acids, Unsaturated / pharmacology,  physiology*
Fluorescence Polarization
Linoleic Acids / pharmacology
Linolenic Acids / pharmacology
Membrane Fluidity* / drug effects
Oleic Acids / pharmacology
Tetrahymena / genetics,  ultrastructure*
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 0/Linolenic Acids; 0/Oleic Acids

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