| Modulation of markers associated with tumor aggressiveness in human breast cancer cell lines by N-(4-hydroxyphenyl) retinamide. | |
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MedLine Citation:
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PMID: 7547508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The retinoid N-(hydroxyphenyl) retinamide (4-HPR) appears to be a promising tool for chemoprevention of breast carcinoma, and clinical trials to evaluate its effect are in progress. However, its action on tumor cells has remained largely undefined. We report here that 4-HPR induced apoptosis and/or differentiation in breast cancer cell lines, independent of hormone receptor status and retinoic acid receptor expression, although it was slightly more efficient in inhibiting proliferation of estrogen receptor-positive cells. 4-HPR up-modulated expression of several differentiation markers (class 1 HLA, laminin, and beta 1 integrin chain) and down-regulated expression of molecules associated with tumor progression, including the p185/HER2 oncoprotein, the epidermal growth factor receptor, and the M(r) 67,000 laminin receptor. These data suggest that 4-HPR could exert a beneficial effect by inhibiting cell proliferation and modulating breast tumor aggressiveness. |
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Authors:
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R Pellegrini; A Mariotti; E Tagliabue; R Bressan; G Bunone; D Coradini; G Della Valle; F Formelli; L Cleris; P Radice |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research Volume: 6 ISSN: 1044-9523 ISO Abbreviation: Cell Growth Differ. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-11-09 Completed Date: 1995-11-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100024 Medline TA: Cell Growth Differ Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 863-9 Citation Subset: IM |
Affiliation:
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Dipartimento di Oncologia Sperimentale, Istituto Nazionale Tumori, Milano, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticarcinogenic Agents
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pharmacology* Apoptosis / drug effects Blotting, Northern Breast Neoplasms / pathology* Cell Differentiation / drug effects Cell Division / drug effects Fenretinide / pharmacology* Gene Expression / physiology Humans Receptors, Estrogen / physiology Receptors, Progesterone / physiology Tumor Cells, Cultured / drug effects Tumor Markers, Biological* |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Receptors, Estrogen; 0/Receptors, Progesterone; 0/Tumor Markers, Biological; 65646-68-6/Fenretinide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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