Document Detail

Modulation of markers associated with tumor aggressiveness in human breast cancer cell lines by N-(4-hydroxyphenyl) retinamide.
MedLine Citation:
PMID:  7547508     Owner:  NLM     Status:  MEDLINE    
The retinoid N-(hydroxyphenyl) retinamide (4-HPR) appears to be a promising tool for chemoprevention of breast carcinoma, and clinical trials to evaluate its effect are in progress. However, its action on tumor cells has remained largely undefined. We report here that 4-HPR induced apoptosis and/or differentiation in breast cancer cell lines, independent of hormone receptor status and retinoic acid receptor expression, although it was slightly more efficient in inhibiting proliferation of estrogen receptor-positive cells. 4-HPR up-modulated expression of several differentiation markers (class 1 HLA, laminin, and beta 1 integrin chain) and down-regulated expression of molecules associated with tumor progression, including the p185/HER2 oncoprotein, the epidermal growth factor receptor, and the M(r) 67,000 laminin receptor. These data suggest that 4-HPR could exert a beneficial effect by inhibiting cell proliferation and modulating breast tumor aggressiveness.
R Pellegrini; A Mariotti; E Tagliabue; R Bressan; G Bunone; D Coradini; G Della Valle; F Formelli; L Cleris; P Radice
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research     Volume:  6     ISSN:  1044-9523     ISO Abbreviation:  Cell Growth Differ.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-09     Completed Date:  1995-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100024     Medline TA:  Cell Growth Differ     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  863-9     Citation Subset:  IM    
Dipartimento di Oncologia Sperimentale, Istituto Nazionale Tumori, Milano, Italy.
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MeSH Terms
Anticarcinogenic Agents / pharmacology*
Apoptosis / drug effects
Blotting, Northern
Breast Neoplasms / pathology*
Cell Differentiation / drug effects
Cell Division / drug effects
Fenretinide / pharmacology*
Gene Expression / physiology
Receptors, Estrogen / physiology
Receptors, Progesterone / physiology
Tumor Cells, Cultured / drug effects
Tumor Markers, Biological*
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Receptors, Estrogen; 0/Receptors, Progesterone; 0/Tumor Markers, Biological; 65646-68-6/Fenretinide

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