| Modulation of mammalian apoptotic pathways by intracellular protozoan parasites. | |
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MedLine Citation:
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PMID: 22168464 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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During intracellular parasitic infections, pathogens and host cells take part in a complex web of events that are crucial for the outcome of the infection. Modulation of host cell apoptosis by pathogens attracted the attention of scientists during the last decade. Apoptosis is an efficient mechanism used by the host to control infection and limit pathogen multiplication and dissemination. In order to ensure completion of their complex life cycles and to guarantee transmission between different hosts, intracellular parasites have developed mechanisms to block apoptosis and sustain the viability of their host cells. Here, we review how some of the most prominent intracellular protozoan parasites modulate the main mammalian apoptotic pathways by emphasizing the advances from the last decade, which have begun to dissect this dynamic and complex interaction. |
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Authors:
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V Rodrigues; A Cordeiro-da-Silva; M Laforge; A Ouaissi; R Silvestre; J Estaquier |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-13 |
Journal Detail:
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Title: Cellular microbiology Volume: - ISSN: 1462-5822 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883691 Medline TA: Cell Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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CNRS FRE 3235, Université Paris Descartes, Paris Université Laval, Centre de recherche en Infectiologie, Québec, Canada Parasite Disease Group, Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal Departamento de Ciências Biológicas, Faculdade de Farmácia da Universidade do Porto, Porto, Portugal. |
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