Document Detail

Modulation of macrophage phagocytic activity by cell wall components of Candida albicans.
MedLine Citation:
PMID:  7656326     Owner:  NLM     Status:  MEDLINE    
Cell wall components of the pathogenic yeast Candida albicans have been shown to possess significant immunomodulatory activity both in vivo and in vitro. We have previously found that an ethylenediamine (EDA) extract of the Candida cell wall exhibits significant immunosuppressive activity. In an effort to further characterize the immunomodulatory activity of the EDA extract, we attempted to determine the effect of this extract on macrophage phagocytic activity. Our results show that nonelicited peritoneal macrophages treated for 24 or 48 hr with the EDA extract fail to phagocytize Candida yeast cells normally. We have observed that the phagocytosis of Candida is mediated by a combination of lectin-like receptor-, Fc receptor-, and complement receptor-type 3 (CR3)-dependent processes. Results show, however, that the most efficient uptake of this organism is dependent on CR3-mediated phagocytosis. Experiments carried out under various opsonic conditions suggest that the level of CR3-mediated phagocytosis of Candida is depressed following EDA extract treatment. These results show that a substantial mechanism of macrophage phagocytosis is depressed following contact with cell wall components of Candida.
I Szabo; L Guan; T J Rogers
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cellular immunology     Volume:  164     ISSN:  0008-8749     ISO Abbreviation:  Cell. Immunol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-02     Completed Date:  1995-10-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  182-8     Citation Subset:  IM    
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
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MeSH Terms
Candida albicans / immunology*
Cell Wall / chemistry,  immunology
Fungal Proteins / immunology
Glycoproteins / immunology
Immunosuppressive Agents*
Interferon-gamma / pharmacology
Macrophage-1 Antigen / physiology
Macrophages, Peritoneal / immunology*
Mice, Inbred BALB C
Receptors, Fc / physiology
Grant Support
Reg. No./Substance:
0/Ethylenediamines; 0/Fungal Proteins; 0/Glycoproteins; 0/Immunosuppressive Agents; 0/Macrophage-1 Antigen; 0/Receptors, Fc; 82115-62-6/Interferon-gamma

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