| Modulation of lymphocyte adrenergic receptors by hormones and anti-asthmatic drugs. | |
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MedLine Citation:
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PMID: 2993626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Viable lymphocytes were used to investigate the binding of physiological concentrations of hormones and therapeutic concentrations of anti-asthmatic drugs to [3H]dihydroalprenolol (DHA, beta antagonist) and [3H]prazosin (alpha antagonist) receptor sites. All studied drugs and hormones inhibited the specific binding of prazosin to receptors identified with 10(-4)M phentolamine. Similar concentrations of drugs and hormones, with the exception of prostaglandin F2 alpha and cimetidine, inhibited the specific binding of DHA to lymphocyte receptors identified with 10(-7)M propranolol. These results confirm current mechanisms of hormone and drug action in asthma. |
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Authors:
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W R Williams; B H Davies |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical & laboratory immunology Volume: 16 ISSN: 0141-2760 ISO Abbreviation: J Clin Lab Immunol Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-10-07 Completed Date: 1985-10-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7808987 Medline TA: J Clin Lab Immunol Country: ITALY |
Other Details:
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Languages: eng Pagination: 131-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asthma
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drug therapy Binding, Competitive Dihydroalprenolol / metabolism Hormones / pharmacology* Humans Kinetics Lymphocytes / metabolism* Prazosin / metabolism Propranolol / metabolism Receptors, Adrenergic, alpha / drug effects, metabolism* Receptors, Adrenergic, beta / drug effects, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 19216-56-9/Prazosin; 525-66-6/Propranolol; 60106-89-0/Dihydroalprenolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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