Document Detail

Modulation of long chain fatty acid unsaturation by dietary copper.
MedLine Citation:
PMID:  2697135     Owner:  NLM     Status:  MEDLINE    
Research over the past 20 years into the effect of copper on fatty acid profiles in several species suggests that copper has a unique effect on long chain fatty acid metabolism. Copper supplementation in the pig and rat and copper deficiency in the rat, mouse and human indicates that inadequate copper intake (or genetic copper deficiency in the brindled mouse and in Menke's disease) impairs the ability to monounsaturate long chain saturated fatty acids and that, conversely, copper supplementation (greater than 150 mg/kg diet) usually increases monounsaturated fatty acids. Several recent studies of copper deficiency in the rat suggest that our interpretation of these effects needs to be more refined since membrane fatty acid profiles do not appear as sensitive to the effects of copper depletion as triglyceride fatty acid profiles. This suggests that changes in long chain fatty acid metabolism other than desaturation may also be affected by copper.
S C Cunnane
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  258     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-04-04     Completed Date:  1990-04-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-95     Citation Subset:  IM    
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada.
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MeSH Terms
Arachidonic Acids / metabolism
Copper / deficiency,  metabolism*
Fatty Acid Desaturases / metabolism
Fatty Acids, Unsaturated / metabolism*
Triglycerides / analysis
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids, Unsaturated; 0/Triglycerides; 7440-50-8/Copper; EC 1.14.19.-/Fatty Acid Desaturases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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