Document Detail

Modulation of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by dopamine receptor agonists and antagonists in mice.
MedLine Citation:
PMID:  8739308     Owner:  NLM     Status:  MEDLINE    
The effects of various agonist and antagonists of dopamine D1 and D2 receptors on lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) production was investigated in mice. Pretreatment of animals with bromocryptine or quinpirole, agonists of dopamine D2 receptors caused a blunting of both the TNF-alpha and NO responses to LPS injected intraperitoneally. Sulpiride, an antagonist of dopamine D2 receptors, decreased the LPS-induced TNF-alpha plasma levels in a dose-dependent manner and inhibited the LPS-induced NO production by peritoneal macrophages. Bromocryptine or quinpirole blunted both the TNF-alpha and NO response to LPS. SCH-23390, an antagonist of dopamine D1 receptors did not alter LPS-induced TNF-alpha production, but inhibited LPS-induced NO production. These results indicate that while the D2 subtype of dopamine receptors is involve in the modulation of both LPS-induced TNF-alpha and NO production, dopamine D1 receptors only regulate the production of NO. Since several drugs possess effect on dopamine D2 receptors, the present observations may be of clinical relevance.
G Haskó; C Szabó; K Merkel; A Bencsics; B Zingarelli; V Kvetan; E S Vizi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology letters     Volume:  49     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-10-17     Completed Date:  1996-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  IM    
Department of Pharmacology, Hungarian Academy of Sciences, Budapest, Hungary.
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MeSH Terms
Dopamine Agonists / pharmacology*
Dopamine Antagonists / pharmacology*
Lipopolysaccharides / immunology*
Macrophages, Peritoneal / metabolism
Nitric Oxide / biosynthesis*
Receptors, Dopamine D2 / physiology*
Tumor Necrosis Factor-alpha / physiology*
Reg. No./Substance:
0/Dopamine Agonists; 0/Dopamine Antagonists; 0/Lipopolysaccharides; 0/Receptors, Dopamine D2; 0/Tumor Necrosis Factor-alpha; 10102-43-9/Nitric Oxide

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