Document Detail

Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis.
MedLine Citation:
PMID:  9566600     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that chronic administration of SR-3 (a 1:4 mixture of alpha-linolenic and linoleic acid) affects spatial learning, thermoregulation, pain threshold and protection from seizures. The mode of action is unknown. One possible explanation is that the preparation induces changes in the fatty acids profile and in the cholesterol level in the neuronal membrane. This study used 15 independent groups of rats (n = 12) which were given either saline, mineral oil (vehicle) or SR-3 (25 mg/kg) for 0, 1, 2, 3, or 4 weeks. The learning performance was measured in the Morris Water tank and the fatty acids profile and the cholesterol level were examined by the GC method in synaptosomes obtained from the frontal cortex of the rats. SR-3 improved the learning performance and induced major changes in the neuronal membrane composition, such as an increase in the total level of fatty acids, an increase in the level of essential fatty acids and a decrease in the cholesterol level. Those changes occurred after 3 weeks of treatment. The biochemical variables can predict the behavioral variables but not vice versa. The changes in the neuronal membrane may result in a modification of the membrane fluidity, which may, in turn, enhance cognitive and neuropharmacological effects.
S Yehuda; S Rabinovitz; D I Mostofsky
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochemical research     Volume:  23     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-19     Completed Date:  1998-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  627-34     Citation Subset:  IM    
Department of Psychology, Bar Ilan University, Ramat Gan, Israel. YEHUDAS@ASHUR.CC.BIU.AC.IL
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MeSH Terms
Cholesterol / analysis,  metabolism
Fatty Acids / analysis,  metabolism*
Fatty Acids, Essential / pharmacology*
Frontal Lobe / drug effects,  metabolism*
Linoleic Acid / pharmacology
Linolenic Acids / pharmacology*
Maze Learning / drug effects*,  physiology
Mineral Oil / pharmacology
Regression Analysis
Synaptosomes / chemistry,  drug effects,  metabolism*
Time Factors
alpha-Linolenic Acid / pharmacology
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Essential; 0/Linolenic Acids; 0/SR 3 linolenic acid; 2197-37-7/Linoleic Acid; 463-40-1/alpha-Linolenic Acid; 57-88-5/Cholesterol; 8020-83-5/Mineral Oil

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