| Modulation of inflammation by vitamin E and C supplementation prior to anterior cruciate ligament surgery. | |
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MedLine Citation:
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PMID: 19111610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Muscle atrophy commonly follows anterior cruciate ligament (ACL) injury and surgery. Proinflammatory cytokines can induce and exacerbate oxidative stress, potentiating muscle atrophy. The purpose of this study was to evaluate the influence of prior antioxidant (AO) supplementation on circulating cytokines following ACL surgery. A randomized, double-blind, placebo-controlled trial was conducted in men undergoing ACL surgery, who were randomly assigned to either: (1) AO (200 IU of vitamin E (50% d-alpha-tocopheryl acetate and 50% d-alpha-tocopherol) and 500 mg ascorbic acid), or (2) matching placebos (PL). Subjects took supplements twice daily for 2 weeks prior to and up to 12 weeks after surgery. Each subject provided five blood samples: (1) baseline (Bsl, prior to supplementation and approximately 2 weeks prior to surgery), (2) presurgery (Pre), (3) 90 min, (4) 72 h, and (5) 7 days postsurgery. Following surgery, inflammation and muscle damage increased in both groups, as assessed by increased circulating IL-6, C-reactive protein, and creatine kinase. During AO supplementation, plasma alpha-T and AA increased while gamma-T concentrations decreased significantly (P< 0.05). At 90 min the AO group displayed a significant decrease in AA, an inverse correlation between AA and (interleukin) IL-8 (r(2)= 0.50, P< 0.05), and a significantly lower IL-10 response than that of the PL group. IL-10 was significantly elevated at 90 min and 72 h in the PL group. In summary, our findings show that circulating inflammatory cytokines increase and AO supplementation attenuated the increase in IL-10 in patients post-ACL surgery. |
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Authors:
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Tyler Barker; Scott W Leonard; Roy H Trawick; Thomas B Martins; Carl R Kjeldsberg; Harry R Hill; Maret G Traber |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-11-27 |
Journal Detail:
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Title: Free radical biology & medicine Volume: 46 ISSN: 1873-4596 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-09 Completed Date: 2009-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 599-606 Citation Subset: IM |
Affiliation:
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The Orthopedic Specialty Hospital, Murray, UT 84107, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anterior Cruciate Ligament / immunology*, injuries, surgery Ascorbic Acid / administration & dosage* C-Reactive Protein / genetics, metabolism Creatine Kinase / blood Cytokines / blood Dietary Supplements* Double-Blind Method Humans Inflammation Male Muscular Atrophy, Spinal / blood, etiology, prevention & control* Reconstructive Surgical Procedures / adverse effects alpha-Tocopherol / administration & dosage*, analogs & derivatives, metabolism gamma-Tocopherol / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/gamma-Tocopherol; 50-81-7/Ascorbic Acid; 59-02-9/alpha-Tocopherol; 9007-41-4/C-Reactive Protein; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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