Document Detail

Modulation of in vivo antibody responses by cholera toxin.
MedLine Citation:
PMID:  163279     Owner:  NLM     Status:  MEDLINE    
Treatment of mice with an exotoxin (0.01 mug to 1.0 mug) purified from Vibrio cholerae culture filtrates markedly influenced the immune response to sheep erythrocytes (SRBC) and the Escherichia coli lipopolysaccharide (LPS). Simultaneous administration of the toxin (CT) with antigen resulted in a delayed appearance of antibody plaque-forming cells (PFC) during the first few days after immunization, followed by a marked enhancement of both IgM and IgG PFC. The secondary immune response to SRBC was also similarly affected when CT was given together with a second inoculation of SRBC; i.e., a delay in appearance of hemolytic PFC followed by a markedly enhanced IgM and IgG PFC response. Treatment of mice with cholera toxin 1 to 3 days before SRBC or LPS was immunosuppressive. The effect of CT on the level of splenic cyclic AMP appeared related to the effects on antibody formation.
J R Kateley; L Kasarov; H Friedman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  114     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-05-21     Completed Date:  1975-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-4     Citation Subset:  AIM; IM    
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MeSH Terms
Adjuvants, Immunologic*
Antibody Formation*
Antibody-Producing Cells / immunology
Complement System Proteins
Cyclic AMP / metabolism
Erythrocytes / immunology
Escherichia coli / immunology
Hemolytic Plaque Technique
Immune Sera
Immunoglobulin G
Immunologic Memory
Lipopolysaccharides / immunology
Mice, Inbred BALB C
Polysaccharides, Bacterial
Rabbits / immunology
Sheep / immunology
Toxins, Biological / pharmacology*
Vibrio cholerae
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antigens; 0/Immune Sera; 0/Immunoglobulin G; 0/Lipopolysaccharides; 0/Polysaccharides, Bacterial; 0/Toxins, Biological; 60-92-4/Cyclic AMP; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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