Document Detail

Modulation in reproductive tissue redox profile in sexually receptive female rats after short-term exposure to male chemical cues.
MedLine Citation:
PMID:  19188278     Owner:  NLM     Status:  MEDLINE    
It is well known that antioxidants play an important role in sperm fertility, but there is no data on the literature regarding the effect of male chemical cues in the antioxidant defenses of the female reproductive tract. Here, we evaluated oxidative parameters in ovaries and uterus of virgin female rats isolated from contact to males and exposed only to male-soiled bedding (MSB). Four-month-old Wistar (regular 4-day cyclic) virgin female rats were utilized from proestrus to estrus phase of the reproductive cycle for experimental exposure. In an isolated room, female rats were exposed for 90 min to MSB. For biochemical assays, female rats were killed by decapitation at 30, 90, 180, and 240 min after the end of exposure, and the ovaries and uterus were removed for further analysis. Antioxidant enzyme activities (superoxide dismutase, catalase, and glutathione peroxidase), the nonenzymatic antioxidant potential (total radical-trapping antioxidant parameter), and the oxidative damage parameters (thiobarbituric acid-reactive species and carbonyl content) were analyzed. We observed an increase in the nonenzymatic antioxidant potential and diminished free radical oxidative damage in uterine tissue, 30 and 90 min after exposure. Furthermore, in ovaries, enzymatic defenses were modulated distinctly along the 240 min after exposure. MSB exposure modulates the antioxidant profile in ovaries and uterus of receptive female rats. It is possible that the modifications in the oxidative profile of the female genital tract may have important implications in the process of fertilization.
Guilherme Antônio Behr; Leonardo Lisbôa da Motta; Marcos Roberto de Oliveira; Max William Soares Oliveira; Daniel Pens Gelain; José Cláudio Fonseca Moreira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-02
Journal Detail:
Title:  Chemical senses     Volume:  34     ISSN:  1464-3553     ISO Abbreviation:  Chem. Senses     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-23     Completed Date:  2009-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8217190     Medline TA:  Chem Senses     Country:  England    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  IM    
Centro de Estudos em Estresse Oxidativo (Lab. 32), Depto Bioquímica, Universidade Federal do Rio Grande do Sul. Av. Ramiro Barcelos, 2600 Anexo, CEP 90035-003, Porto Alegre, RS, Brazil.
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MeSH Terms
Antioxidants / metabolism*
Catalase / metabolism
Glutathione Peroxidase / metabolism
Lipid Peroxidation
Ovary / metabolism*
Oxidative Stress / drug effects
Peroxidases / metabolism*
Protein Carbonylation
Rats, Wistar
Reproduction / physiology*
Superoxide Dismutase / metabolism
Thiobarbituric Acid Reactive Substances / metabolism
Time Factors
Uterus / metabolism*
Reg. No./Substance:
0/Antioxidants; 0/Thiobarbituric Acid Reactive Substances; EC 1.11.1.-/Peroxidases; EC; EC Peroxidase; EC Dismutase

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