| Modulation of higher-primate adrenal androgen secretion with estrogen-alone or estrogen-plus-progesterone intervention. | |
| | |
MedLine Citation:
|
PMID: 23149869 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: Circulating adrenal steroids rise during the menopausal transition in most middle-aged women and may contribute to differences in between-women symptoms and ultimate health outcomes. However, the mechanisms for this shift in adrenal steroid production in middle-aged women are not known. This study aims to determine whether hormone therapy (HT) for 1 year can modulate adrenal androgen production. METHODS: Younger (9.8 [0.4] years, n = 20) and older (22.7 [0.4] years, n = 37) female laboratory macaques were ovariectomized, and each group was treated with different regimens of HT for up to 1 year. Changes in adrenal histology and circulating adrenal androgens were monitored after estrogen-alone (E) or estrogen plus progesterone (E + P) treatment, and these changes were compared with the same measures in similarly aged animals given vehicle. RESULTS: Zona reticularis area, serum dehydroepiandrosterone (DHEA), and serum dehydroepiandrosterone sulfate (DHEAS) were higher in younger vehicle-treated animals compared with older vehicle-treated animals (P < 0.02). Both E and E + P treatments decreased circulating DHEAS in the younger group (P < 0.05). Although E treatment also decreased DHEAS in the older group, this was not statistically significant. In contrast, E + P treatment in the older group resulted in a rise in DHEAS over vehicle, which was significantly higher than the results of E treatment (P < 0.01). Circulating concentrations of DHEA exhibited similar trends, but these changes did not reach statistical significance. CONCLUSIONS: These data demonstrate that intervention with ovarian steroids can modulate adrenal androgen production in female higher primates and that both animal age and type of HT regimen determine adrenal response. |
| | |
Authors:
|
Alan J Conley; Frank Z Stanczyk; John H Morrison; Pawel Borowicz; Kurt Benirschke; Nancy A Gee; Bill L Lasley |
Related Documents
:
|
16182409 - A longitudinal study to explain strategies to change weight and muscles among normal we... 19711809 - Marital status, marital transitions, and body weight. 21059599 - Derivation of new reference tables for human heart weights in light of increasing body ... 20360759 - Markers of inflammation and weight change in middle-aged adults: results from the prosp... 12167219 - In utero and lactational exposure to ammonium perchlorate in drinking water: effects on... 23393279 - Neither male gonadal androgens nor female reproductive costs drive development of sexua... 2759789 - Changes in rod sensitivity through adulthood. 3762129 - Cardiopulmonary hypoxic response 5 years postpneumonectomy in beagles. 18482509 - A 1-year intraindividual evaluation of maximum bite force in children wearing a removab... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-12 |
Journal Detail:
|
Title: Menopause (New York, N.Y.) Volume: - ISSN: 1530-0374 ISO Abbreviation: Menopause Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9433353 Medline TA: Menopause Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the 1Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, Davis, CA; 2Department of Obstetrics and Gynecology and Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA; 3Department of Neuroscience, Mount Sinai School of Medicine, New York, NY; 4Department of Animal and Range Sciences, North Dakota State University, Fargo, ND; 5Department Pathology, School of Medicine, University of California at San Diego, San Diego, CA; and 6Center for Health and the Environment, University of California at Davis, Davis, CA; and 7California National Primate Research Center, University ofCalifornia at Davis, Davis, CA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of watermelon supplementation on arterial stiffness and wave reflection amplitude in postmen...
Next Document: Do Italian surgeons use antibiotic prophylaxis in thyroid surgery? Results from a national study (UE...