| Modulation of hemorrhagic shock by intestinal mucosal NG-nitro-L-arginine and L-arginine in the anesthetized rat. | |
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MedLine Citation:
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PMID: 10446897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maintaining intestinal function protects against shock of various origins. Nitric oxide (NO) can protect tissues. The present research examined whether the presence of 50 microM NG-nitro-L-arginine (NOLARG), a nitric oxide synthase (NOS) inhibitor, or L-arginine (LARG), the substrate of NOS, in the jejunal lumen of the anesthetized rat could affect the progress of hemorrhagic shock. The jejunal lumen was perfused with saline containing 14C-inulin and 3H2O to measure net H2O absorption and absorptive site blood flow (ASBF). Luminal NOx (NO3- +NO2-) secretion into the gut effluent and blood pressure (BP) were also measured. The animals were bled to and maintained at 40 mmHg for 60 min and then reinfused. Survival time was significantly decreased in luminally-perfused NOLARG animals, but was significantly increased in LARG perfused animals. Most deaths occurred during the hemorrhage periods. Animals perfused with LARG through the ileal lumen required significantly less blood to be reinfused to maintain blood pressure during the hemorrhage periods. There were not significant differences in BP among surviving animals. Net H2O absorption and ASBF were significantly decreased only in NOLARG-perfused animals in the period just before and after reinfusion. There were no significant differences in luminal NOx secretion among the groups. Thus, intestinal mucosal NOS substrates or antagonists modulate the progress of hemorrhagic shock, but the mechanism was not defined in these experiments. |
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Authors:
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D Mailman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: 12 ISSN: 1073-2322 ISO Abbreviation: Shock Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-09-23 Completed Date: 1999-09-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 155-60 Citation Subset: IM |
Affiliation:
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Biology Department, University of Houston, TX 77204, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / metabolism, pharmacology* Biological Transport Blood Pressure / drug effects Enzyme Inhibitors / pharmacology* Female Hemodynamics / drug effects Intestinal Mucosa / drug effects*, metabolism Nitric Oxide / metabolism Nitric Oxide Synthase / antagonists & inhibitors Nitroarginine / pharmacology* Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Shock, Hemorrhagic / drug therapy*, mortality, physiopathology Survival Rate Water / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 74-79-3/Arginine; 7732-18-5/Water; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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