Document Detail

Modulation of free radicals and superoxide dismutases by age and dietary restriction.
MedLine Citation:
PMID:  1965567     Owner:  NLM     Status:  MEDLINE    
Reducing dietary intake has been shown to be the most effective means for modulating aging processes in laboratory rodents. Dietary restriction has also been shown to be a modulator of membrane lipid peroxidation and cytosolic antioxidant status. In the present study, anti-radical action of dietary restriction was investigated further by quantitating the formation of the superoxide radical, hydroxyl radical and hydrogen peroxide by liver microsomes from rats of various ages. The results show that the ad libitum fed group maintained a higher production of superoxide and hydroxyl radicals when compared to the food restricted group of the same age. Hydrogen peroxide formation followed the same trend but was statistically greater only at 3 and 6 months of age. The food restricted group tended to show a higher superoxide dismutase (SOD) activity in both cytosolic and mitochondrial fractions than ad libitum fed controls. These data indicate that the free radical activity observed in the liver microsomes of ad libitum fed rats can be attenuated by dietary restriction, thereby providing a possible biochemical mechanism for its anti-lipoxidative action on membrane lipid peroxidation as reported in an earlier study. This action may in part underlie the life span-prolonging action of food restriction.
D W Lee; B P Yu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Aging (Milan, Italy)     Volume:  2     ISSN:  0394-9532     ISO Abbreviation:  Aging (Milano)     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-07-02     Completed Date:  1991-07-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9102503     Medline TA:  Aging (Milano)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  357-62     Citation Subset:  IM    
Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.
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MeSH Terms
Aging / metabolism*
Free Radicals
Hydrogen Peroxide / metabolism
Hydroxides / metabolism
Hydroxyl Radical
Microsomes / metabolism
Mitochondria, Liver / metabolism
Oxygen / metabolism*
Rats, Inbred F344
Superoxide Dismutase / metabolism*
Grant Support
Reg. No./Substance:
0/Free Radicals; 0/Hydroxides; 3352-57-6/Hydroxyl Radical; 7722-84-1/Hydrogen Peroxide; 7782-44-7/Oxygen; EC Dismutase

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