Document Detail


Modulation of fetal inflammatory response on exposure to lipopolysaccharide by chorioamnion, lung, or gut in sheep.
MedLine Citation:
PMID:  19801145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We hypothesized that fetal lipopolysaccharide exposures to the chorioamnion, lung, or gut would induce distinct systemic inflammatory responses.
STUDY DESIGN: Groups of 5-7 time-mated ewes were used to surgically isolate the fetal respiratory and the gastrointestinal systems from the amniotic compartment. Outcomes were assessed at 124 days gestational age, 2 days and 7 days after lipopolysaccharide (10 mg, Escherichia coli 055:B5) or saline solution infusions into the fetal airways or amniotic fluid.
RESULTS: Lipopolysaccharide induced systemic inflammatory changes in all groups in the blood, lung, liver, and thymic lymphocytes. Changes in lymphocytes in the posterior mediastinal lymph node draining lung and gut, occurred only after direct contact of lipopolysaccharide with the fetal lung or gut.
CONCLUSION: Fetal systemic inflammatory responses occurred after chorioamnion, lung, or gut exposures to lipopolysaccharide. The organ responses differed based on route of the fetal exposure.
Authors:
Boris W Kramer; Suhas G Kallapur; Timothy J M Moss; Ilias Nitsos; Graeme P Polglase; John P Newnham; Alan H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-10-04
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  202     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-25     Completed Date:  2010-03-01     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77.e1-9     Citation Subset:  AIM; IM    
Copyright Information:
2010. Published by Mosby, Inc.
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid
Animals
Animals, Newborn / physiology
Chorioamnionitis / physiopathology
Endotoxins / pharmacology
Female
Fetal Blood / chemistry
Inflammation / physiopathology
Intestines
Lipopolysaccharides / pharmacology*
Lung / drug effects,  physiology
Lymphocytes / drug effects,  pathology
Neutrophils / pathology
Pregnancy
Sheep
Thymus Gland
Grant Support
ID/Acronym/Agency:
HD-12714/HD/NICHD NIH HHS; HD-57869/HD/NICHD NIH HHS; HL-08 70711/HL/NHLBI NIH HHS; HL-65397/HL/NHLBI NIH HHS; K08 HL070711/HL/NHLBI NIH HHS; K08 HL070711-05/HL/NHLBI NIH HHS; R01 HD012714/HD/NICHD NIH HHS; R01 HD012714-28/HD/NICHD NIH HHS; R01 HD057869/HD/NICHD NIH HHS; R01 HD057869-01A1/HD/NICHD NIH HHS; R01 HL065397/HL/NHLBI NIH HHS; R01 HL065397-08/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Endotoxins; 0/Lipopolysaccharides
Comments/Corrections

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