| Modulation of fetal inflammatory response on exposure to lipopolysaccharide by chorioamnion, lung, or gut in sheep. | |
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MedLine Citation:
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PMID: 19801145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We hypothesized that fetal lipopolysaccharide exposures to the chorioamnion, lung, or gut would induce distinct systemic inflammatory responses. STUDY DESIGN: Groups of 5-7 time-mated ewes were used to surgically isolate the fetal respiratory and the gastrointestinal systems from the amniotic compartment. Outcomes were assessed at 124 days gestational age, 2 days and 7 days after lipopolysaccharide (10 mg, Escherichia coli 055:B5) or saline solution infusions into the fetal airways or amniotic fluid. RESULTS: Lipopolysaccharide induced systemic inflammatory changes in all groups in the blood, lung, liver, and thymic lymphocytes. Changes in lymphocytes in the posterior mediastinal lymph node draining lung and gut, occurred only after direct contact of lipopolysaccharide with the fetal lung or gut. CONCLUSION: Fetal systemic inflammatory responses occurred after chorioamnion, lung, or gut exposures to lipopolysaccharide. The organ responses differed based on route of the fetal exposure. |
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Authors:
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Boris W Kramer; Suhas G Kallapur; Timothy J M Moss; Ilias Nitsos; Graeme P Polglase; John P Newnham; Alan H Jobe |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-10-04 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 202 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-03-01 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 77.e1-9 Citation Subset: AIM; IM |
Copyright Information:
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2010. Published by Mosby, Inc. |
Affiliation:
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University Medical Center Maastricht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid Animals Animals, Newborn / physiology Chorioamnionitis / physiopathology Endotoxins / pharmacology Female Fetal Blood / chemistry Inflammation / physiopathology Intestines Lipopolysaccharides / pharmacology* Lung / drug effects, physiology Lymphocytes / drug effects, pathology Neutrophils / pathology Pregnancy Sheep Thymus Gland |
| Grant Support | |
ID/Acronym/Agency:
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HD-12714/HD/NICHD NIH HHS; HD-57869/HD/NICHD NIH HHS; HL-08 70711/HL/NHLBI NIH HHS; HL-65397/HL/NHLBI NIH HHS; K08 HL070711-05/HL/NHLBI NIH HHS; R01 HD012714-28/HD/NICHD NIH HHS; R01 HD057869-01A1/HD/NICHD NIH HHS; R01 HD057869-03/HD/NICHD NIH HHS; R01 HL065397-08/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Lipopolysaccharides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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