| Modulation of eicosanoid release from anaphylactic guinea-pig heart with 5-benzoyl-a-methyl-2-thiophene acetic acid (tiaprofenic acid). | |
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MedLine Citation:
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PMID: 3841634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of infusion of the non-steroidal anti-inflammatory drugs (NSAID), tiaprofenic acid (2.2 micrograms/min or 10.0 micrograms/min) and indomethacin (1.0 microgram/min) on the release of leukotriene (LT) C4-like immunoreactivity, thromboxane (TX) B2 and 6-keto-prostaglandin (PG) F1 alpha from isolated perfused anaphylactic guinea-pig hearts were investigated. Tiaprofenic acid at both concentrations used significantly inhibited anaphylactic release of TXB2 and 6-keto-PGF1 alpha as did indomethacin (1.0 microgram/min) which was, however, about ten times more potent in this respect. Release of immunoreactive LTC4-like material was not influenced by the lower concentration of tiaprofenic acid used (2.2 micrograms/min), but significantly enhanced by the higher concentration (10.0 micrograms/min). Thus, the effect of tiaprofenic acid on eicosanoid release by the anaphylactic heart is very similar to that of indomethacin without any differential inhibition of TXB2 or 6-keto-PGF1 alpha formation. |
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Authors:
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T Simmet; H R Wittenberg; B A Peskar |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 278 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-03-28 Completed Date: 1986-03-28 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 207-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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metabolism Anaphylaxis / metabolism* Animals Anti-Inflammatory Agents / pharmacology* Eicosanoic Acids / metabolism* Guinea Pigs Indomethacin / pharmacology Male Myocardium / metabolism* Propionates / pharmacology* Propionic Acids / pharmacology* SRS-A / pharmacology Thromboxane B2 / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Eicosanoic Acids; 0/Propionates; 0/Propionic Acids; 0/SRS-A; 33005-95-7/tiaprofenic acid; 53-86-1/Indomethacin; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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