Document Detail

Modulation of eicosanoid release from anaphylactic guinea-pig heart with 5-benzoyl-a-methyl-2-thiophene acetic acid (tiaprofenic acid).
MedLine Citation:
PMID:  3841634     Owner:  NLM     Status:  MEDLINE    
The effects of infusion of the non-steroidal anti-inflammatory drugs (NSAID), tiaprofenic acid (2.2 micrograms/min or 10.0 micrograms/min) and indomethacin (1.0 microgram/min) on the release of leukotriene (LT) C4-like immunoreactivity, thromboxane (TX) B2 and 6-keto-prostaglandin (PG) F1 alpha from isolated perfused anaphylactic guinea-pig hearts were investigated. Tiaprofenic acid at both concentrations used significantly inhibited anaphylactic release of TXB2 and 6-keto-PGF1 alpha as did indomethacin (1.0 microgram/min) which was, however, about ten times more potent in this respect. Release of immunoreactive LTC4-like material was not influenced by the lower concentration of tiaprofenic acid used (2.2 micrograms/min), but significantly enhanced by the higher concentration (10.0 micrograms/min). Thus, the effect of tiaprofenic acid on eicosanoid release by the anaphylactic heart is very similar to that of indomethacin without any differential inhibition of TXB2 or 6-keto-PGF1 alpha formation.
T Simmet; H R Wittenberg; B A Peskar
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  278     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-03-28     Completed Date:  1986-03-28     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  207-14     Citation Subset:  IM    
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MeSH Terms
6-Ketoprostaglandin F1 alpha / metabolism
Anaphylaxis / metabolism*
Anti-Inflammatory Agents / pharmacology*
Eicosanoic Acids / metabolism*
Guinea Pigs
Indomethacin / pharmacology
Myocardium / metabolism*
Propionates / pharmacology*
Propionic Acids / pharmacology*
SRS-A / pharmacology
Thromboxane B2 / metabolism
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Eicosanoic Acids; 0/Propionates; 0/Propionic Acids; 0/SRS-A; 33005-95-7/tiaprofenic acid; 53-86-1/Indomethacin; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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