Document Detail

Modulation of drug release rate of diltiazem-HCl from hydrogel matrices of succinic acid-treated ispaghula husk.
MedLine Citation:
PMID:  10934737     Owner:  NLM     Status:  MEDLINE    
The feasibility of using succinic acid-treated ispaghula husk in matrix-based tablets of diltiazem-HCl was investigated. The sample prepared using 4:1 weight ratio of ispaghula husk to succinic acid showed improved swelling and gelling. A 3(2) factorial design was employed to investigate the effect of amount of succinic acid-treated ispaghula husk and dicalcium phosphate (DCP) on the percentage of the drug dissolved in 60, 300, and 480 min from the compressed tablets. The results of multiple linear regression analysis revealed that the significance of the amount of succinic acid-treated ispaghula husk was greater in magnitude than that of the amount of DCP in controlling the drug release. Acceptable batches were identified from a contour plot with constraints on the percentage drug released at the three sampling times. A mathematical model was also evolved to describe the entire dissolution profile. The results of F-test revealed that the Higuchi model fits well to the in vitro dissolution data. The tablets showed considerable radial and axial swelling in distilled water. Succinic acid-treated ispaghula husk can be used as an economical hydrophilic matrixing agent.
M C Gohel; A F Amin; M T Chhabaria; M K Panchal; A N Lalwani
Related Documents :
1789917 - Pregnancy-associated idiopathic intrahepatic cholestasis. hypotheses of physiopathology...
6839487 - 125i radioimmunoassay of serum ursodeoxycholyl conjugates.
17204097 - Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatmen...
4008567 - Rapid and accurate reversed-phase high-performance liquid chromatographic determination...
21568307 - Lizard epidermal gland secretions. ii. chemical characterization of the generation glan...
6809737 - Formation of 6-oxoprostaglandin f1 alpha, 6,15-dioxoprostaglandin f1 alpha, and monohyd...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  5     ISSN:  1083-7450     ISO Abbreviation:  Pharm Dev Technol     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-30     Completed Date:  2000-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
Department of Pharmaceutical Technology, L. M. College of Pharmacy, Navrangpura, Ahmedabad, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Calcium Channel Blockers / administration & dosage*
Diltiazem / administration & dosage*,  chemistry
Psyllium / administration & dosage*
Succinic Acid / pharmacology
Reg. No./Substance:
0/Calcium Channel Blockers; 110-15-6/Succinic Acid; 25852-47-5/Hydrogel; 42399-41-7/Diltiazem; 8063-16-9/Psyllium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Scaleup of a high-shear granulation process using a normalized impeller work parameter.
Next Document:  Drug release from film-coated chlorpheniramine maleate nonpareil beads: effect of water-soluble poly...