Document Detail


Modulation of drug release rate of diltiazem-HCl from hydrogel matrices of succinic acid-treated ispaghula husk.
MedLine Citation:
PMID:  10934737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The feasibility of using succinic acid-treated ispaghula husk in matrix-based tablets of diltiazem-HCl was investigated. The sample prepared using 4:1 weight ratio of ispaghula husk to succinic acid showed improved swelling and gelling. A 3(2) factorial design was employed to investigate the effect of amount of succinic acid-treated ispaghula husk and dicalcium phosphate (DCP) on the percentage of the drug dissolved in 60, 300, and 480 min from the compressed tablets. The results of multiple linear regression analysis revealed that the significance of the amount of succinic acid-treated ispaghula husk was greater in magnitude than that of the amount of DCP in controlling the drug release. Acceptable batches were identified from a contour plot with constraints on the percentage drug released at the three sampling times. A mathematical model was also evolved to describe the entire dissolution profile. The results of F-test revealed that the Higuchi model fits well to the in vitro dissolution data. The tablets showed considerable radial and axial swelling in distilled water. Succinic acid-treated ispaghula husk can be used as an economical hydrophilic matrixing agent.
Authors:
M C Gohel; A F Amin; M T Chhabaria; M K Panchal; A N Lalwani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  5     ISSN:  1083-7450     ISO Abbreviation:  Pharm Dev Technol     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-30     Completed Date:  2000-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Technology, L. M. College of Pharmacy, Navrangpura, Ahmedabad, India. mukeshgohel@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Calcium Channel Blockers / administration & dosage*
Diltiazem / administration & dosage*,  chemistry
Hydrogel
Psyllium / administration & dosage*
Solubility
Succinic Acid / pharmacology
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 110-15-6/Succinic Acid; 25852-47-5/Hydrogel; 42399-41-7/Diltiazem; 8063-16-9/Psyllium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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