Document Detail

Modulation of cytotoxic effect of anticancer drugs by dipyridamole in HeLa cells in vitro.
MedLine Citation:
PMID:  2285237     Owner:  NLM     Status:  MEDLINE    
Exponentially growing HeLa cells were treated with various antitumor drugs and dipyridamole (DP), and the cell growth inhibition ratio was determined. Enhanced growth inhibition was found in combined treatment with DP and 5-fluorouracil, 1-hexylcarbamoyl-5-fluorouracil, methotrexate, adriamycin, daunomycin, 4'-0-tetrahydropyranyl-adriamycin, actinomycin D and vincristine. In contrast, reduction of the cytotoxic effect of cytosine arabinoside and enocitabine was found when these were combined with DP.
H Kusumoto; Y Maehara; Y Sakaguchi; S Kohnoe; R Kumashiro; K Sugimachi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  10     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1990 Nov-Dec
Date Detail:
Created Date:  1991-03-15     Completed Date:  1991-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1643-5     Citation Subset:  IM    
Cancer Center, Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Antineoplastic Agents / pharmacology*
Cell Division / drug effects
Cell Survival / drug effects*
Dipyridamole / pharmacology*
Drug Interactions
Hela Cells / cytology,  drug effects
Reg. No./Substance:
0/Antineoplastic Agents; 58-32-2/Dipyridamole

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