Document Detail

Modulation of cytokines, resistin, and distribution of adipose tissue in C57BL/6 mice by different high-fat diets.
MedLine Citation:
PMID:  21872438     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To investigate whether changing the lipid source induces metabolic changes and/or modulates the adipose tissue distribution in mice fed with a high-fat (HF) diet. METHODS: C57BL/6 mice were subjected to a 10-wk control diet (10% fat) or an HF diet (60% fat) containing lard (HF-L), olive oil (HF-O), sunflower oil, or canola oil. Food intake and body weight were measured. At euthanasia, blood was collected and adipose tissue was dissected. Serum hormones and cytokines were determined. RESULTS: The plasma insulin levels were higher in the HF-L and HF-O groups than in the other three groups (P < 0.0001). The levels of resistin were highest in the HF-L and HF-O groups (P < 0.0001). Leptin expression was also highest in these two groups (P < 0.0001). Of the four groups, interleukin-6 was expressed at the highest level in the HF-L group (P < 0.0005), whereas adiponectin was expressed at the lowest level (P < 0.0001). The accumulation of subcutaneous and visceral adipose tissues was higher in the HF-L group compared with the other groups. This group was hypertrophic because of excess subcutaneous fat and epididymal fat in the adipocytes. However, the ratio of subcutaneous to visceral fat was significantly lower in the HF-L and HF-O groups compared with the other groups. CONCLUSION: In mice fed fat-rich diets, the level of adipokines, the distribution of adipose tissue, and the metabolism of carbohydrates are more significantly influenced by the lipid content rather than the absolute amount of lipid.
Mariana Catta-Preta; Marcela Anjos Martins; Tatiana Marlowe Cunha Brunini; Antonio Claudio Mendes-Ribeiro; Carlos Alberto Mandarim-de-Lacerda; Marcia Barbosa Aguila
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-26
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  -     ISSN:  1873-1244     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Laboratory of Pharmacology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
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