Document Detail

Modulation of control of muscle sympathetic nerve activity during orthostatic stress in humans.
MedLine Citation:
PMID:  15475533     Owner:  NLM     Status:  MEDLINE    
We tested the hypothesis that orthostatic stress would modulate the arterial baroreflex (ABR)-mediated beat-by-beat control of muscle sympathetic nerve activity (MSNA) in humans. In 12 healthy subjects, ABR control of MSNA (burst incidence, burst strength, and total activity) was evaluated by analysis of the relation between beat-by-beat spontaneous variations in diastolic blood pressure (DAP) and MSNA during supine rest (CON) and at two levels of lower body negative pressure (LBNP: -15 and -35 mmHg). At -15 mmHg LBNP, the relation between burst incidence (bursts per 100 heartbeats) and DAP showed an upward shift from that observed during CON, but the further shift seen at -35 mmHg LBNP was only marginal. The relation between burst strength and DAP was shifted upward at -15 mmHg LBNP (vs. CON) and further shifted upward at -35 mmHg LBNP. At -15 mmHg LBNP, the relation between total activity and DAP was shifted upward from that obtained during CON and further shifted upward at -35 mmHg LBNP. These results suggest that ABR control of MSNA is modulated during orthostatic stress and that the modulation is different between a mild (nonhypotensive) and a moderate (hypotensive) level of orthostatic stress.
Masashi Ichinose; Mitsuru Saito; Takeshi Ogawa; Keiji Hayashi; Narihiko Kondo; Takeshi Nishiyasu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  287     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-11     Completed Date:  2004-11-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H2147-53     Citation Subset:  IM    
Institute of Health and Sport Sciences, Univ. of Tsukuba, Tsukuba City, Ibaraki 305-8574, Japan.
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MeSH Terms
Arteries / innervation*
Blood Pressure
Lower Body Negative Pressure
Muscle, Skeletal / innervation*
Stress, Physiological / etiology,  physiopathology*
Supine Position*
Sympathetic Nervous System / physiopathology*

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