Document Detail

MedLine Citation:
PMID:  21427120     Owner:  NLM     Status:  Publisher    
The development of the heart is a complex process during which several types of cells progressively contribute to shape a four-chambered pumping organ. Over the last decades our understanding of the specification and transcriptional regulation of cardiac development has been greatly augmented and progressively also our understanding of the functional bases of the cardiac electrophysiology during embryogenesis. The nascent heart gradually acquires distinct cellular and functional characteristics, such as the formation of contractile structures, the development of conductive capabilities and soon thereafter the coordinated conduction of the electrical impulse, in order to fulfill its functional properties. Over the last decade we have learnt about the consequences of impairing cardiac morphogenesis, which in many cases leads to congenital heart diseases, however we are not aware yet of the consequences of impairing electrical function during cardiogenesis. The most prevalent cardiac arrhythmia is atrial fibrillation, although its genetic etiology remains rather elusive. Recent genome wide association studies have identified several genetic variants highly associated with atrial fibrillation. Among them, genetic variants located in chromosome 4q25 are adjacent to PITX2, a transcription factor known to play a critical role in left-right asymmetry as well as during cardiogenesis. We provide herein insights into the cellular and molecular links between PITX2 and atrial fibrillation.
Diego Franco; Ana Chinchilla; Houria Daimi; Jorge N Dominguez; Amelia Aránega
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-22
Journal Detail:
Title:  Cardiovascular research     Volume:  -     ISSN:  1755-3245     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Cardiovascular Development Group, Department of Experimental Biology, University of Jaén, Jáen, Spain.
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