Document Detail

Modulation of chronotropic and inotropic heart vagus actions as a non-pressor effect of angiotensin II in the anaesthetized rat.
MedLine Citation:
PMID:  9712176     Owner:  NLM     Status:  MEDLINE    
(1) In vagotomized, anaesthetized rats, effects of stimulation of cardiac N. vagus (2-25 Hz) on cardiac and circulatory functions were studied: we recorded transient reductions in heart rate (HR), in left-ventricular systolic pressure (LV Ps), in maximal change in left-ventricular pressure development (dp/dt)max and in mean arterial pressure (MAP, A. femoralis). (2) Bolus injection of angiotensin II (AII, 2.5-100 microg/kg body weight) caused (a) transient increases in HR, LV Ps and MAP (pressor effects, maximal changes occurred within 3 min after injection), and (b) dose-dependently reduced effects of vagus stimulation (non-pressor effects, recorded 10 min after injection). Due to fast breakdown of All in the circulatory system, all observed vagus stimulation effects were completely recovered within 1 h after injection. (3) Plasma concentration of AII was recorded with a highly specific radioimmunoassay: 10 min after AII injection (non-pressor range), plasma concentration was clearly higher than physiological levels in all experiments with 10 microg AII/kg at least. (4) Treatment with propranolol (beta-adrenoceptor blocker, 1 mg/kg body weight) did not reduce the vagus effects alone, but decreased the modulatory AII effects. This result hints at the activation of sympathetic beta-adrenergic receptors by AII counteracting the parasympathetic cardiac control.
C Wicher; G A Biewald; M Hüller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory peptides     Volume:  74     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-11-06     Completed Date:  1998-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  151-8     Citation Subset:  IM    
Institute of Physiology II (Heart-Circulation Physiology), Medical Faculty, Friedrich Schiller University Jena, Germany.
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MeSH Terms
Angiotensin II / pharmacology*
Depression, Chemical
Heart / drug effects*,  physiology
Heart Rate / drug effects*
Vagus Nerve / drug effects*,  physiology
Vasoconstrictor Agents / pharmacology*
Reg. No./Substance:
0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II

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