Document Detail


Modulation of chronic enteric infection by distant oral infection.
MedLine Citation:
PMID:  10726543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This investigation determined the effects of a distant oral infection (Porphyromonas gingivalis) on a concurrent local enteric infection (Echerichia coli). A modified murine subcutaneous tissue chamber model was used. Subcutaneously implanted chambers with different microbial makeups were monitored for sloughing and their contents assayed for prostaglandin E2. Bilaterally implanted chamber experiments revealed that a distant "chronic" (immunization with heat-killed organism, followed by live challenge) P. gingivalis infection offered protection against a local chronic E. coli infection, as evidenced by delaying the time for 50% of the chambers to reject from day 19 to day 25 and a statistically significant prostaglandin E2 decrease from 529.4 +/- 176.6 ng/ml to 191.5 +/- 100.9 ng/ml (p < 0.01) (Mann-Whitney test). An acute (live challenge only) distant P. gingivalis infection or immunization with the heat-killed organism alone had no effect on "chronic" E. coli infection in this model. These data suggest that the presence of low-grade chronic oral infection may modify the responses to other infectious challenges.
Authors:
J E Bergman; R R Arnold; M Trope; S Offenbacher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endodontics     Volume:  25     ISSN:  0099-2399     ISO Abbreviation:  J Endod     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-03-28     Completed Date:  2000-03-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  747-51     Citation Subset:  D    
Affiliation:
Department of Endodontics, University of North Carolina School of Dentistry, Chapel Hill 27599-7450, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteroidaceae Infections / complications*,  physiopathology
Chronic Disease
Colony Count, Microbial
Diffusion Chambers, Culture
Dinoprostone / metabolism
Escherichia coli Infections / complications*,  metabolism,  physiopathology
Female
Mice
Mice, Inbred BALB C
Mouth Diseases / microbiology*
Porphyromonas gingivalis / physiology*
Statistics, Nonparametric
Superinfection* / metabolism,  microbiology,  physiopathology
Chemical
Reg. No./Substance:
363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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