| Modulation of chemically initiated and promoted skin tumorigenesis in CD-1 mice by dietary glucarate. | |
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MedLine Citation:
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PMID: 2509679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of dietary calcium glucarate as a chemopreventative agent has been tested in the mouse skin tumorigenesis system. Skin tumorigenesis was initiated in mice of the CD-1 strain with 7,12-dimethylbenz(a)anthracene (DMBA), then promoted with twice weekly applications of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) for 13 weeks. The mice were fed a regular chow diet, or a chow diet fortified with calcium glucarate (128 mmol/kg diet), or with equimolar calcium as calcium gluconate (negative calcium control). When mice were fed calcium glucarate throughout both the initiation and promotion phases papilloma formation was inhibited by over 30%. Transfer of these DMBA-initiated, TPA promoted CD-1 mice to chow diet after 13 weeks on the calcium glucarate-supplemented diet, resulted in an increase in the number of skin papillomas within 3 weeks to the level of those seen in control animals maintained exclusively on the chow diet. When calcium glucarate feeding was restricted to either the initiation or promotion phases, papilloma formation was inhibited by 25%. Dietary calcium gluconate had no effect on papilloma formation in the CD-1 mouse system, but increased the calcium concentration in the skin to the same extent as that of calcium glucarate. The data indicate that the elevation of the normally low levels of glucarate in the body through supplementation, results in a marked alteration in the retention, activity and/or metabolism of xenobiotics. |
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Authors:
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C Dwivedi; A A Downie; T E Webb |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer Volume: 9 ISSN: 0731-8898 ISO Abbreviation: J. Environ. Pathol. Toxicol. Oncol. Publication Date: 1989 May-Jun |
Date Detail:
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Created Date: 1989-12-05 Completed Date: 1989-12-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8501420 Medline TA: J Environ Pathol Toxicol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 253-9 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings 57007. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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9,10-Dimethyl-1,2-benzanthracene Animals Calcium / analysis Diet Female Glucaric Acid / pharmacology* Mice Skin / analysis Skin Neoplasms / chemically induced, prevention & control* Sugar Acids / pharmacology* Tetradecanoylphorbol Acetate |
| Grant Support | |
ID/Acronym/Agency:
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CA 38125/CA/NCI NIH HHS; CA P-30-CA-16058-13/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sugar Acids; 16561-29-8/Tetradecanoylphorbol Acetate; 25525-21-7/Glucaric Acid; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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