Document Detail

Modulation of cellular immune response by orbifloxacin in noninfected and E. coli-infected mice.
MedLine Citation:
PMID:  16237956     Owner:  NLM     Status:  MEDLINE    
The studies were conducted on noninfected and Escherichia (E) coli-infected mice treated with orbifloxacin administered orally 10 times at 24-hr intervals at a dose of 2.5 mg/kg. Orbifloxacin did not change the activity of peritoneal macrophages in noninfected mice. Administration of orbifloxacin in E. coli-infected mice modulated the effects of infection on the percentage of phagocyting macrophages, the percentage of NBT-positive cells, and nitric oxide production. Orbifloxacin did not affect the synthesis and release of interleukin-1 by macrophages. Orbifloxacin exerted a modulating effect on the subsets of lymphocytes in thymus, spleen, and mesenteric lymph node cells in noninfected and E. coli-infected mice.
Marianna Szczypka; Bartosz Gaweda; Bozena Obmińska-Mrukowicz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Immunopharmacology and immunotoxicology     Volume:  27     ISSN:  0892-3973     ISO Abbreviation:  Immunopharmacol Immunotoxicol     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-21     Completed Date:  2005-12-15     Revised Date:  2009-05-14    
Medline Journal Info:
Nlm Unique ID:  8800150     Medline TA:  Immunopharmacol Immunotoxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  461-72     Citation Subset:  IM    
Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Agricultural University, Wrocław, Poland.
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MeSH Terms
Ciprofloxacin / administration & dosage,  analogs & derivatives*,  pharmacology
Escherichia coli
Escherichia coli Infections / immunology*
Interleukin-1 / immunology
Macrophages, Peritoneal / drug effects*,  immunology,  microbiology
Nitric Oxide / biosynthesis
T-Lymphocyte Subsets / drug effects,  immunology
Thymus Gland / cytology
Reg. No./Substance:
0/Interleukin-1; 0/orbifloxacin; 10102-43-9/Nitric Oxide; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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