Document Detail


Modulation of cell proliferation by protein proteinase inhibitors. A new analytical approach.
MedLine Citation:
PMID:  2462427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human alpha 1-proteinase inhibitor (alpha 1-antitrypsin) and bovine pancreatic trypsin inhibitor both inhibit cell-surface proteolytic activity in human fibroblasts. At the inhibitory concentrations, these proteins also inhibit cellular proliferation, as assayed by a microassay based on spectrophotometry of fixed and stained cells. Despite testing a wide range of proteinase inhibitor concentrations, no evidence was found for mitogenic or growth-stimulatory activity. ovomucoid was inactive against cell-surface proteinase activity and did not inhibit cellular proliferation.
Authors:
G K Scott; C A Tse
Related Documents :
16816207 - Holdfast formation in motile swarmer cells optimizes surface attachment during caulobac...
22527307 - Growth inhibition of human lens epithelial cells by short hairpin rna in transcription ...
20936277 - Mechanisms of bacillus cereus biofilm formation: an investigation of the physicochemica...
3314767 - Isolation and composition of the constitutive agglutinins from haploid saccharomyces ce...
20184667 - Expression profiles of proex c and ki67 in squamous cell carcinoma in situ of the skin ...
15857957 - Pushing forces drive the comet-like motility of microtubule arrays in dictyostelium.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological chemistry Hoppe-Seyler     Volume:  369 Suppl     ISSN:  0177-3593     ISO Abbreviation:  Biol. Chem. Hoppe-Seyler     Publication Date:  1988 May 
Date Detail:
Created Date:  1989-02-07     Completed Date:  1989-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503054     Medline TA:  Biol Chem Hoppe Seyler     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Auckland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Division / drug effects*
Enzyme-Linked Immunosorbent Assay
Fibroblasts / drug effects,  metabolism
Humans
Protease Inhibitors / pharmacology*
Staining and Labeling
Chemical
Reg. No./Substance:
0/Protease Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Enzymatic resynthesis of the "reactive site" bond in the modified aprotinin derivatives [s...
Next Document:  Reduction of the cardiopulmonary response to endotoxin by the administration of aprotinin.