| Modulation of cell proliferation by protein proteinase inhibitors. A new analytical approach. | |
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MedLine Citation:
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PMID: 2462427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human alpha 1-proteinase inhibitor (alpha 1-antitrypsin) and bovine pancreatic trypsin inhibitor both inhibit cell-surface proteolytic activity in human fibroblasts. At the inhibitory concentrations, these proteins also inhibit cellular proliferation, as assayed by a microassay based on spectrophotometry of fixed and stained cells. Despite testing a wide range of proteinase inhibitor concentrations, no evidence was found for mitogenic or growth-stimulatory activity. ovomucoid was inactive against cell-surface proteinase activity and did not inhibit cellular proliferation. |
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Authors:
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G K Scott; C A Tse |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological chemistry Hoppe-Seyler Volume: 369 Suppl ISSN: 0177-3593 ISO Abbreviation: Biol. Chem. Hoppe-Seyler Publication Date: 1988 May |
Date Detail:
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Created Date: 1989-02-07 Completed Date: 1989-02-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8503054 Medline TA: Biol Chem Hoppe Seyler Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 131-5 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Auckland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Division
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drug effects* Enzyme-Linked Immunosorbent Assay Fibroblasts / drug effects, metabolism Humans Protease Inhibitors / pharmacology* Staining and Labeling |
| Chemical | |
Reg. No./Substance:
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0/Protease Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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