Document Detail

Modulation of cell proliferation by protein proteinase inhibitors. A new analytical approach.
MedLine Citation:
PMID:  2462427     Owner:  NLM     Status:  MEDLINE    
Human alpha 1-proteinase inhibitor (alpha 1-antitrypsin) and bovine pancreatic trypsin inhibitor both inhibit cell-surface proteolytic activity in human fibroblasts. At the inhibitory concentrations, these proteins also inhibit cellular proliferation, as assayed by a microassay based on spectrophotometry of fixed and stained cells. Despite testing a wide range of proteinase inhibitor concentrations, no evidence was found for mitogenic or growth-stimulatory activity. ovomucoid was inactive against cell-surface proteinase activity and did not inhibit cellular proliferation.
G K Scott; C A Tse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological chemistry Hoppe-Seyler     Volume:  369 Suppl     ISSN:  0177-3593     ISO Abbreviation:  Biol. Chem. Hoppe-Seyler     Publication Date:  1988 May 
Date Detail:
Created Date:  1989-02-07     Completed Date:  1989-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503054     Medline TA:  Biol Chem Hoppe Seyler     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Department of Biochemistry, University of Auckland.
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MeSH Terms
Cell Division / drug effects*
Enzyme-Linked Immunosorbent Assay
Fibroblasts / drug effects,  metabolism
Protease Inhibitors / pharmacology*
Staining and Labeling
Reg. No./Substance:
0/Protease Inhibitors

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