| Modulation of the cell division cycle by human papillomavirus type 18 E4. | |
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MedLine Citation:
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PMID: 12368334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The life cycle of human papillomaviruses (HPVs) is tightly coupled to the differentiation program of their host epithelial cells. HPV E4 gene expression is first observed in the parabasal layers of squamous epithelia, suggesting that the E4 gene product contributes to the mechanism of differentiation-dependent virus replication, although its biological function remains unclear. We analyzed the effect of HPV type 18 E4 on cell proliferation and found that E4 expression induced cell cycle arrest at the G(2)/M boundary. The functional region of E4 necessary for the growth arrest activity was located in the central portion of the molecule, and this activity was independent of the E4-mediated collapse of cytokeratin intermediate filament structures. |
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Authors:
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Tomomi Nakahara; Akiko Nishimura; Masakazu Tanaka; Takaharu Ueno; Akinori Ishimoto; Hiroyuki Sakai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of virology Volume: 76 ISSN: 0022-538X ISO Abbreviation: J. Virol. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-10-07 Completed Date: 2002-11-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
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Languages: eng Pagination: 10914-20 Citation Subset: IM |
Affiliation:
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Laboratory of Gene Analysis, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo-Ku, Kyoto 606-8507, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle Cell Division Cell Line Cercopithecus aethiops G2 Phase Hela Cells Humans Keratins / metabolism Mitosis Oncogene Proteins, Viral / genetics, metabolism* Papillomaviridae / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Oncogene Proteins, Viral; 0/oncogene protein E1, Human papillomavirus type 18; 0/oncogene protein E4, Human papillomavirus type 18; 68238-35-7/Keratins |
| Comments/Corrections | |
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