Document Detail

Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity.
MedLine Citation:
PMID:  17458181     Owner:  NLM     Status:  MEDLINE    
The rising incidence of obesity, as a disorder of energy metabolism, has provoked a search for pharmacological agents that either increase energy expenditure or reduce food intake. The fatty acid oxidation pathway, and its rate-limiting enzyme carnitine palmitoyltransferase (CPT)-1 are potential targets for the treatment of obesity. The modulation of CPT-1 may simultaneously affect energy metabolism and food intake to aid in the management of obesity. Both the inhibition and enhancement of CPT-1 activity are currently under investigation as strategies for the treatment of obesity. In this review, key data on both sides of the 'CPT-1 activity balance' as they relate to obesity therapy are discussed.
Francis P Kuhajda; Gabriele V Ronnett
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in investigational drugs (London, England : 2000)     Volume:  8     ISSN:  1472-4472     ISO Abbreviation:  Curr Opin Investig Drugs     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-26     Completed Date:  2007-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100965718     Medline TA:  Curr Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  312-7     Citation Subset:  IM    
The Johns Hopkins University School of Medicine, Department of Pathology, UMB BioPark, Building 1, 800 West Baltimore Street, Suite 150, Baltimore, MD 21201, USA.
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MeSH Terms
Carnitine O-Palmitoyltransferase / antagonists & inhibitors*,  metabolism*
Enzyme Activation / drug effects
Fatty Acids / metabolism
Lactones / pharmacology,  therapeutic use
Models, Biological
Molecular Structure
Obesity / drug therapy*,  enzymology,  pathology
Reg. No./Substance:
0/Fatty Acids; 0/Lactones; EC O-Palmitoyltransferase

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