| Modulation of the cardiomyocyte cell cycle in genetically altered animals. | |
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MedLine Citation:
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PMID: 15201157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many forms of cardiovascular disease are associated with cardiomyocyte loss via apoptosis and/or necrosis. Although there is currently debate regarding the level at which adult cardiomyocytes can reenter the cell cycle and proliferate, it is clear that the intrinsic regenerative growth capacity is insufficient to reverse the progression to failure in badly injured hearts. The ability to reactivate cardiomyocyte proliferation in damaged hearts might permit regenerative growth, provided that the nascent cells are able to participate in a functional syncytium with the surviving myocardium. In this review, techniques commonly used to monitor cardiomyocyte cell cycle activity in normal and injured hearts are discussed. In addition, several genetic models are described wherein the expression of fundamental cell cycle regulatory proteins has been altered in cardiomyocytes. |
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Authors:
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Loren J Field |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1015 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-06-17 Completed Date: 2004-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 160-70 Citation Subset: IM |
Affiliation:
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Herman B Wells Center and Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, 46202, USA. ljfield@iupui.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified* Antigens, Polyomavirus Transforming / immunology Cell Cycle* Models, Genetic Myocardium / cytology*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Polyomavirus Transforming |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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