| Modulation of cardiac mitochondrial membrane fluidity by age and calorie intake. | |
| | |
MedLine Citation:
|
PMID: 9895215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of the present study was to determine the effects of dietary restriction (DR) on the age-related changes in membrane fluidity, fatty acid composition and free radical damage of mitochondrial membranes obtained from the rat left ventricle. Mitochondrial membrane preparations were obtained from the left ventricles of 6- and 24-month-old, male, Fischer 344 rats that were allowed to eat throughout their life either ad lib (Group A) or only 60% of the amount consumed by the ad lib fed group (Group B). Our results show that the membrane fluidity of the 24 month Group A hearts was less than that of the 6 month group A hearts. No differences in membrane fluidity were observed between the 6 and 24 month DR groups. The fatty acid composition of the mitochondrial membranes of the two ad lib fed groups differed: the long-chain polyunsaturated 22:4 fatty acid was higher in the older group, although linoleic acid (18:2) was lower. DR eliminated the differences. No statistically significant difference in the overall polyunsaturated fatty acid content was noted. However, the peroxidizability index was higher in the membranes of the 24 month Group A hearts but not in the 24 month Group B hearts. Finally, the degree of lipid damage, as assessed in vitro by the induced production of reactive oxygen species, was elevated in the 24 month Group A hearts. No difference was observed between the young and old DR groups. Considered together, these results suggest that DR maintains the integrity of the cardiac mitochondrial membrane fluidity by minimizing membrane damage through modulation of membrane fatty acid profile. |
| | |
Authors:
|
J Lee; B P Yu; J T Herlihy |
Related Documents
:
|
2044505 - Maternal and umbilical venous plasma lipid concentrations at delivery in the mare. 8011635 - Regulation of membrane cholesterol domains by sterol carrier protein-2. 7863525 - Chronic inhalation exposure and phospholipids in lung surfactant and tissue. 21783895 - Damage to lung epithelial cells and lining fluid antioxidant defense by humic acid. 394825 - Mycelial lipids as an aid in identifying rust fungi in culture-cronartium fusiforme. 11641615 - Inhibitory effect of short-term bile duct ligation on hepatic cytochrome p450 of bile a... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Free radical biology & medicine Volume: 26 ISSN: 0891-5849 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 1999 Feb |
Date Detail:
|
Created Date: 1999-03-31 Completed Date: 1999-03-31 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 260-5 Citation Subset: IM |
Affiliation:
|
Department of Physiology, University of Texas Health Science Center at San Antonio, 78284, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology* Analysis of Variance Animals Energy Intake* Fatty Acids / analysis Lipid Peroxidation / physiology Male Membrane Fluidity / physiology* Mitochondria, Heart / physiology* Rats Rats, Inbred F344 |
| Grant Support | |
ID/Acronym/Agency:
|
AG-11088/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The cardiac acetylcholine-activated, inwardly rectifying K+-channel subunit GIRK1 gives rise to an i...
Next Document: Maternal administration of superoxide dismutase and catalase in phenytoin teratogenicity.