Document Detail

Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair.
MedLine Citation:
PMID:  21245355     Owner:  NLM     Status:  MEDLINE    
Herein we investigated a new strategy for the modulation of cardiac macrophages to a reparative state, at a predetermined time after myocardial infarction (MI), in aim to promote resolution of inflammation and elicit infarct repair. The strategy employed intravenous injections of phosphatidylserine (PS)-presenting liposomes, mimicking the anti-inflammatory effects of apoptotic cells. Following PS-liposome uptake by macrophages in vitro and in vivo, the cells secreted high levels of anti-inflammatory cytokines [transforming growth factor β (TGFβ) and interleukin 10 (IL-10)] and upregulated the expression of the mannose receptor--CD206, concomitant with downregulation of proinflammatory markers, such as tumor necrosis factor α (TNFα) and the surface marker CD86. In a rat model of acute MI, targeting of PS-presenting liposomes to infarct macrophages after injection via the femoral vein was demonstrated by magnetic resonance imaging (MRI). The treatment promoted angiogenesis, the preservation of small scars, and prevented ventricular dilatation and remodeling. This strategy represents a unique and accessible approach for myocardial infarct repair.
Tamar Harel-Adar; Tamar Ben Mordechai; Yoram Amsalem; Micha S Feinberg; Jonathan Leor; Smadar Cohen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-18
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  108     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  2011-03-23     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1827-32     Citation Subset:  IM    
Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
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MeSH Terms
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Interleukin-10 / secretion
Macrophages / physiology*,  secretion
Mice, Inbred BALB C
Myocardial Infarction / pathology*
Myocardium / pathology*
Phosphatidylserines / administration & dosage*
Rats, Sprague-Dawley
Transforming Growth Factor beta / secretion
Reg. No./Substance:
0/Liposomes; 0/Phosphatidylserines; 0/Transforming Growth Factor beta; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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