Document Detail

Modulation of cardiac autonomic functions in patients with major depression treated with repetitive transcranial magnetic stimulation.
MedLine Citation:
PMID:  17490754     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sub clinical cardiac autonomic imbalance is associated with depression. Clinical improvement produced by antidepressant therapy might alter this autonomic balance. OBJECTIVES: To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) therapy on autonomic functions measured by heart rate variability (HRV) in depression patients and compare it with selective serotonin re-up-take inhibitors (SSRI) therapy. METHODS: Consecutive drug-naïve patients of major depression based on DSM-IV-TR were recruited in this study (n=67). Basal Hamilton depression-rating scale (HDRS) and measures of cardiac autonomic function were recorded and compared with those after two weeks of therapy with rTMS (n=27) and one month after SSRI therapy (n=25). RESULTS: Both therapies produced comparable and significant reduction in HDRS scores. HRV measures indicated that rTMS produced significantly greater reduction in the sympathetic: parasympathetic ratio suggesting improvement in sympathovagal balance. Conventional cardiac autonomic function tests did not differentiate the two therapy effects. CONCLUSIONS: rTMS not only produced antidepressant effects but also ''corrected'' the autonomic imbalance. SSRI was systemically administered and hence by direct cardiac effect, may have masked cardiac effects that would have occurred by the improvement in depression. Alternatively, the neurophysiological ''correction'' with drug therapy may have longer latency, just as with the therapeutic effects.
Kaviraja Udupa; T N Sathyaprabha; Jagadisha Thirthalli; K R Kishore; T R Raju; B N Gangadhar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-08
Journal Detail:
Title:  Journal of affective disorders     Volume:  104     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-02-19     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  231-6     Citation Subset:  IM    
Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur road, Bangalore, 560 029, India.
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MeSH Terms
Autonomic Nervous System / drug effects*,  physiology*
Combined Modality Therapy
Depressive Disorder, Major / drug therapy,  psychology*,  therapy*
Heart Rate / drug effects*,  physiology*
Serotonin Uptake Inhibitors / pharmacology*,  therapeutic use*
Transcranial Magnetic Stimulation / instrumentation*
Vagus Nerve / drug effects*,  physiology*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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