Document Detail


Modulation of carcinoembryonic antigen release by HT-29 colon carcinoma line in the presence of different agents.
MedLine Citation:
PMID:  2444456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we followed the effects of various differentiating agents on the expression of carcinoembryonic antigen (CEA) released into the medium by a colon carcinoma cell line HT-29. Butyric acid 1 mM markedly increased the level of CEA (12-fold in comparison to control levels). 12-O-tetradecanoyl-phorbol-13-acetate (TPA) 50 ng/ml and 5-azacytidine 4 x 10(-6) M increased the amount of CEA, 2- and 1.5-fold respectively. On the other hand retinoic acid 10(-5) M, N methyl-formamide 1% and N,N hexamethylene bisacetamide 2.5 mM decreased CEA 2-, 4- and 3-fold respectively. Our results emphasize that various differentiating agents affect CEA levels differently. Thus changes in CEA levels appear not to be reliable as a marker of a more differentiated phenotype.
Authors:
J Friedman; M Seger; H Levinsky; D Allalouf
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experientia     Volume:  43     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-30     Completed Date:  1987-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1121-2     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel.
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MeSH Terms
Descriptor/Qualifier:
Acetamides / pharmacology
Azacitidine / pharmacology
Butyric Acid
Butyric Acids / pharmacology
Carcinoembryonic Antigen / analysis*
Cell Differentiation / drug effects
Colonic Neoplasms / immunology*
Drug Synergism
Formamides / pharmacology
Humans
Tetradecanoylphorbol Acetate / pharmacology
Tretinoin / pharmacology
Chemical
Reg. No./Substance:
0/Acetamides; 0/Butyric Acids; 0/Carcinoembryonic Antigen; 0/Formamides; 107-92-6/Butyric Acid; 123-39-7/methylformamide; 16561-29-8/Tetradecanoylphorbol Acetate; 302-79-4/Tretinoin; 3073-59-4/hexamethylene bisacetamide; 320-67-2/Azacitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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